ArticleJournal of virology2006
Insights into the selective pressures restricting Pelargonium flower break virus genome variability: Evidence for host adaptation.
Article in Journal of virology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 60 citations in OpenAlex.
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- A global invasion by the thrip, Frankliniella occidentalis: Current virus vector status and its management.Insect science · 2020Review
- Newly emerged resistance-breaking variants of cucumber mosaic virus represent ongoing host-interactive evolution of an RNA virus.Virus evolution · 2020Article
- The transcriptomics of an experimentally evolved plant-virus interaction.Scientific reports · 2016Article
- Constrained evolvability of interferon suppression in an RNA virus.Scientific reports · 2016Article
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- Experimental evolution of an RNA virus in cells with innate immunity defects.Virus evolution · 2015Article
- The evolution and genetics of virus host shifts.PLoS pathogens · 2014Review
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- Epistasis between mutations is host-dependent for an RNA virus.Biology letters · 2013Article
- Mutational fitness effects in RNA and single-stranded DNA viruses: common patterns revealed by site-directed mutagenesis studies.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2010Review
- The evolution of viruses in multi-host fitness landscapes.The open virology journal · 2009Article
- Experimental evolution of plant RNA viruses.Heredity · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The molecular diversity of Pelargonium flower break virus (PFBV) was assessed using a collection of isolates from different geographical origins, hosts, and collecting times. The genomic region examined was 1,828 nucleotides (nt) long and comprised the coding sequences for the movement (p7 and p12) and the coat (CP) proteins, as well as flanking segments including the entire 3' untranslated region (3' UTR). Some constraints limiting viral heterogeneity could be inferred from sequence analyses, such as the conservation of the amino acid sequences of p7 and of the shell domain of the CP, the maintenance of a leucine zipper motif in p12, and the preservation of a particular folding in the 3' UTR. A remarkable covariation, involving five specific amino acid sites, was found in the CP of isolates largely propagated in the local lesion host Chenopodium quinoa and in the progeny of a PFBV variant subjected to serial passages in this host. Concomitant with this covariation, up to 30 nucleotide substitutions in a 1,428-nt region of the viral RNA could be attributable to C. quinoa-specific adaptation, representing one of the most outstanding cases of host-driven genome variation for a plant virus. Globally, the results indicate that the selective pressures exerted by the host play a critical role in shaping PFBV populations and that these populations are likely being selected for at both protein and RNA levels.
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