ArticleJournal of virology2006
Global changes in cellular gene expression during bacteriophage PRD1 infection.
Article in Journal of virology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 78 citations in OpenAlex.
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- Methylation Warfare: Interaction of Pneumococcal Bacteriophages with Their Host.Journal of bacteriology · 2019Article
- Phage or foe: an insight into the impact of viral predation on microbial communities.The ISME journal · 2018Review
- Physiological and transcriptome changes induced by Pseudomonas putida acquisition of an integrative and conjugative element.Scientific reports · 2018Article
- Transcriptome Analysis of a Bloom-Forming CyanobacteriumFrontiers in microbiology · 2018Article
- Novel chaperonins are prevalent in the virioplankton and demonstrate links to viral biology and ecology.The ISME journal · 2017Article
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- Low-level predation by lytic phage phiIPLA-RODI promotes biofilm formation and triggers the stringent response in Staphylococcus aureus.Scientific reports · 2017Article
- Regulation of infection efficiency in a globally abundant marine Bacteriodetes virus.The ISME journal · 2017Article
- Effectiveness of a Lytic Phage SRG1 against Vancomycin-ResistantBioMed research international · 2017Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Virus-induced changes in cellular gene expression and host physiology have been studied extensively. Still, there are only a few analyses covering the entire viral replication cycle and whole-host gene pool expression at the resolution of a single gene. Here we report changes in Escherichia coli gene expression during bacteriophage PRD1 infection using microarray technology. Relative mRNA levels were systematically measured for over 99% of the host open reading frames throughout the infection cycle. Although drastic modifications could be detected in the expression of individual genes, global changes at the whole-genome level were moderate. Notably, the majority of virus-induced changes took place only after the synthesis of virion components, indicating that there is no major reprogramming of the host during early infection. The most highly induced genes encoded chaparones and other stress-inducible proteins.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.