ArticleJournal of the American Society for Mass Spectrometry2006
Fragmentation of oligoribonucleotides from gas-phase ion-electron reactions.
Article in Journal of the American Society for Mass Spectrometry, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Activation of Oligonucleotide Polyanions Using Collisions, Electrons and Photons in a timsOmni Platform.Journal of the American Society for Mass Spectrometry · 2026Article
- Phosphorothioate RNA Analysis by NETD Tandem Mass Spectrometry.Molecular & cellular proteomics : MCP · 2024Article
- Ribonucleic Acid Sequence Characterization by Negative Electron Transfer Dissociation Mass Spectrometry.Analytical chemistry · 2020Article
- What Hinders Electron Transfer Dissociation (ETD) of DNA Cations?Journal of the American Society for Mass Spectrometry · 2017Article
- Label-free, direct localization and relative quantitation of the RNA nucleobase methylations m6A, m5C, m3U, and m5U by top-down mass spectrometry.Nucleic acids research · 2017Article
- Electron capture dissociation of divalent metal-adducted sulfated N-glycans released from bovine thyroid stimulating hormone.Journal of the American Society for Mass Spectrometry · 2013Article
- Structural Characterization of Carbohydrates by Fourier Transform Tandem Mass Spectrometry.Current proteomics · 2011Article
- Identification, localization, and relative quantitation of pseudouridine in RNA by tandem mass spectrometry of hydrolysis products.International journal of mass spectrometry · 2011Article
- Electron detachment dissociation for top-down mass spectrometry of acidic proteins.Chemistry (Weinheim an der Bergstrasse, Germany) · 2011Article
- Characterization of oligodeoxynucleotides and modifications by 193 nm photodissociation and electron photodetachment dissociation.Analytical chemistry · 2010Article
- Top-down mass spectrometry for sequencing of larger (up to 61 nt) RNA by CAD and EDD.Journal of the American Society for Mass Spectrometry · 2010Article
- Negative electron transfer dissociation of glycosaminoglycans.Analytical chemistry · 2010Article
- Infrared multiphoton dissociation of small-interfering RNA anions and cations.Journal of the American Society for Mass Spectrometry · 2010Article
- A mechanistic study of the electron capture dissociation of oligonucleotides.Journal of the American Society for Mass Spectrometry · 2009Article
- EVALUATION OF THE EXPERIMENTAL PARAMETERS WHICH CONTROL ELECTRON DETACHMENT DISSOCIATION, AND THEIR EFFECT ON THE FRAGMENTATION EFFICIENCY OF GLYCOSAMINOGLYCAN CARBOHYDRATES.International journal of mass spectrometry · 2008Article
- Structures, fragmentation, and protonation of trideoxynucleotide CCC mono- and dianions.Journal of the American Society for Mass Spectrometry · 2008Article
- Characterization of phosphate-containing metabolites by calcium adduction and electron capture dissociation.Journal of the American Society for Mass Spectrometry · 2008Article
- Electron photodetachment dissociation of DNA anions with covalently or noncovalently bound chromophores.Journal of the American Society for Mass Spectrometry · 2007Article
- Collision-activated dissociation, infrared multiphoton dissociation, and electron capture dissociation of the Bacillus anthracis siderophore petrobactin and its metal ion complexes.Journal of the American Society for Mass Spectrometry · 2007Article
- Progress in Tandem Mass Spectrometry Data Analysis for Nucleic Acids.Mass spectrometry reviewsReview
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Authors and funding
2 authors.
Funding
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Abstract
We have recently demonstrated that both electron capture dissociation (ECD) and electron detachment dissociation (EDD) can provide complementary sequence-specific cleavage of DNA compared with collision activated dissociation (CAD) and infrared multiphoton dissociation (IRMPD). However, EDD is preferred because of more extensive fragmentation at higher sensitivity (due to its negative ion mode operation). Here, we extend the radical ion chemistry of these two gas-phase ion-electron reaction techniques to the characterization of RNA. Compared with DNA, rather limited information is currently available on the gas-phase fragmentation of RNA. We found that the ECD fragmentation patterns of the oligoribonucleotides A6, C6, and CGGGGC are nucleobase dependent, suggesting that cleavage proceeds following electron capture at the nucleobases. Only limited backbone cleavage was observed in ECD. EDD, on the other hand, provided complete sequence coverage for the RNAs A6, C6, G6, U6, CGGGGC, and GCAUAC. The EDD fragmentation patterns were different from those observed with CAD and IRMPD in that the dominant product ions correspond to d- and w-type ions rather than c- and y-type ions. The minimum differences between oligoribonucleotides suggest that EDD proceeds following direct electron detachment from the phosphate backbone.
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Registered trials
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