ArticleBMC genomics2006
Genomes of Helicobacter pylori from native Peruvians suggest admixture of ancestral and modern lineages and reveal a western type cag-pathogenicity island.
Article in BMC genomics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 68 citations in OpenAlex.
- Article
- Article
- Review
- High Epidermal Growth Factor Receptor Mutation Rates in Peruvian Patients With Non-Small-Cell Lung Cancer: Is It a Matter of Asian Ancestry?Journal of global oncology · 2017Article
- From Evolutionary Advantage to Disease Agents: Forensic Reevaluation of Host-Microbe Interactions and Pathogenicity.Microbiology spectrum · 2017Review
- Whole Genome Sequence and Phylogenetic Analysis ShowFrontiers in cellular and infection microbiology · 2017Article
- Identification of a Latin American-specific BabA adhesin variant through whole genome sequencing of Helicobacter pylori patient isolates from Nicaragua.BMC evolutionary biology · 2016Article
- Helicobacter pylori: Genomic Insight into the Host-Pathogen Interaction.International journal of genomics · 2015Review
- Next-generation sequencing and de novo assembly, genome organization, and comparative genomic analyses of the genomes of two Helicobacter pylori isolates from duodenal ulcer patients in India.Journal of bacteriology · 2012Article
- In silico evolutionary analysis of Helicobacter pylori outer membrane phospholipase A (OMPLA).BMC microbiology · 2012Article
- Comparative genomics of Helicobacter pylori strains of China associated with different clinical outcome.PloS one · 2012Article
- Analysis of multilocus sequence typing for identification of Leptospira isolates in Brazil.Journal of clinical microbiology · 2011Article
- Article
- New implications on genomic adaptation derived from the Helicobacter pylori genome comparison.PloS one · 2011Article
- DNA sequence analysis of South African Helicobacter pylori Vacuolating Cytotoxin Gene (vacA).International journal of molecular sciences · 2011Article
- Anthropological and clinical implications for the structural diversity of the Helicobacter pylori CagA oncoprotein.Cancer science · 2011Article
- Gastric cancer: an infectious disease.Infectious disease clinics of North America · 2010Review
- Article
- CagA C-terminal variations in Helicobacter pylori strains from Colombian patients with gastric precancerous lesions.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2010Article
- Helicobacter pylori--a seasoned pathogen by any other name.Gut pathogens · 2009Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHelicobacter pylori is presumed to be co-evolved with its human host and is a highly diverse gastric pathogen at genetic levels. Ancient origins of H. pylori in the New World are still debatable. It is not clear how different waves of human migrations in South America contributed to the evolution of strain diversity of H. pylori. The objective of our 'phylogeographic' study was to gain fresh insights into these issues through mapping genetic origins of H. pylori of native Peruvians (of Amerindian ancestry) and their genomic comparison with isolates from Spain, and Japan.
resultsFor this purpose, we attempted to dissect genetic identity of strains by fluorescent amplified fragment length polymorphism (FAFLP) analysis, multilocus sequence typing (MLST) of the 7 housekeeping genes (atpA, efp, ureI, ppa, mutY, trpC, yphC) and the sequence analyses of the babB adhesin and oipA genes. The whole cag pathogenicity-island (cagPAI) from these strains was analyzed using PCR and the geographic type of cagA phosphorylation motif EPIYA was determined by gene sequencing. We observed that while European genotype (hp-Europe) predominates in native Peruvian strains, approximately 20% of these strains represent a sub-population with an Amerindian ancestry (hsp-Amerind). All of these strains however, irrespective of their ancestral affiliation harbored a complete, 'western' type cagPAI and the motifs surrounding it. This indicates a possible acquisition of cagPAI by the hsp-Amerind strains from the European strains, during decades of co-colonization.
conclusionOur observations suggest presence of ancestral H. pylori (hsp-Amerind) in Peruvian Amerindians which possibly managed to survive and compete against the Spanish strains that arrived to the New World about 500 years ago. We suggest that this might have happened after native Peruvian H. pylori strains acquired cagPAI sequences, either by new acquisition in cag-negative strains or by recombination in cag positive Amerindian strains.
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