ArticleFEMS immunology and medical microbiology2006
Production and characterization of neutralizing monoclonal antibodies that recognize an epitope in domain 2 of Bacillus anthracis protective antigen.
Article in FEMS immunology and medical microbiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Article
- Progress towards the Development of a NEAT Vaccine for Anthrax II: Immunogen Specificity and Alum Effectiveness in an Inhalational Model.Infection and immunity · 2020Article
- Evaluation of anthrax vaccine safety in 18 to 20 year olds: A first step towards age de-escalation studies in adolescents.Vaccine · 2015Article
- Identification of a conserved B-cell epitope in the equine arteritis virus (EAV) N protein using the pepscan technique.Virus genes · 2013Article
- Article
- A three-dose intramuscular injection schedule of anthrax vaccine adsorbed generates sustained humoral and cellular immune responses to protective antigen and provides long-term protection against inhalation anthrax in rhesus macaques.Clinical and vaccine immunology : CVI · 2012Article
- Article
- Review
- Analysis of defined combinations of monoclonal antibodies in anthrax toxin neutralization assays and their synergistic action.Clinical and vaccine immunology : CVI · 2012Article
- Article
- Epitope characterization of sero-specific monoclonal antibody to Clostridium botulinum neurotoxin type A.Hybridoma (2005) · 2011Article
- Peptide epitope identification by affinity selection on bacteriophage MS2 virus-like particles.Journal of molecular biology · 2011Article
- An antibody directed against the fusion peptide of Junin virus envelope glycoprotein GPC inhibits pH-induced membrane fusion.Journal of virology · 2010Article
- A heterologous helper T-cell epitope enhances the immunogenicity of a multiple-antigenic-peptide vaccine targeting the cryptic loop-neutralizing determinant of Bacillus anthracis protective antigen.Infection and immunity · 2009Article
- Neutralizing monoclonal antibodies directed against defined linear epitopes on domain 4 of anthrax protective antigen.Infection and immunity · 2009Article
- Identification of linear epitopes in Bacillus anthracis protective antigen bound by neutralizing antibodies.The Journal of biological chemistry · 2009Article
- Synthetic peptide vaccine targeting a cryptic neutralizing epitope in domain 2 of Bacillus anthracis protective antigen.Infection and immunity · 2009Article
- Article
- Domain specificity of the human antibody response to Bacillus anthracis protective antigen.Vaccine · 2008Article
- Immunogenicity of Bacillus anthracis protective antigen domains and efficacy of elicited antibody responses depend on host genetic background.Clinical and vaccine immunology : CVI · 2008Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antibodies against the protective antigen (PA) of Bacillus anthracis play a key role in response to infection by this important pathogen. The aim of this study was to produce and characterize monoclonal antibodies (mAbs) specific for PA and to identify novel neutralizing epitopes. Three murine mAbs with high specificity and nanomolar affinity for B. anthracis recombinant protective antigen (rPA) were produced and characterized. Western immunoblot analysis, coupled with epitope mapping using overlapping synthetic peptides, revealed that these mAbs recognize a linear epitope within domain 2 of rPA. Neutralization assays demonstrate that these mAbs effectively neutralize lethal toxin in vitro.
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