ArticleNeurochemical research2006
Decreased nitric oxide production in the rat brain after chronic arsenic exposure.
Article in Neurochemical research, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 55 citations in OpenAlex.
- Cortical Synaptic Reorganization Under Chronic Arsenic Exposure.Neurotoxicity research · 2021Article
- Heavy Metal-Induced Cerebral Small Vessel Disease: Insights into Molecular Mechanisms and Possible Reversal Strategies.International journal of molecular sciences · 2020Review
- Lipid Metabolism Alterations in a Rat Model of Chronic and Intergenerational Exposure to Arsenic.BioMed research international · 2019Article
- Olfactory Dysfunctions and Decreased Nitric Oxide Production in the Brain of Human P301L Tau Transgenic Mice.Neurochemical research · 2016Article
- The effect of arsenic on some antioxidant enzyme activities and lipid peroxidation in various tissues of mirror carp (Cyprinus carpio carpio).Environmental science and pollution research international · 2015Article
- Metal toxicity at the synapse: presynaptic, postsynaptic, and long-term effects.Journal of toxicology · 2012Article
- Arsenic exposure and motor function among children in Bangladesh.Environmental health perspectives · 2011Article
- Risk of erectile dysfunction induced by arsenic exposure through well water consumption in Taiwan.Environmental health perspectives · 2008Article
- Conditioned flavor aversion and brain Fos expression following exposure to arsenic.Toxicology · 2007Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic arsenic exposure is associated with nervous system damage, vascular disease, hepatic and renal damage as well as different types of cancer. Alterations of nitric oxide (NO) in the periphery have been detected after arsenic exposure, and we explored here NO production in the brain. Female Wistar rats were exposed to arsenite in drinking water (4-5 mg/kg/day) from gestation, lactation and until 4 months of age. NOS activity, NO metabolites content, reactive oxygen species production (ROS) and lipid peroxidation (LPx) were determined in vitro in the striatum, and NO production was estimated in vivo measuring citrulline by microdialysis. Exposed animals showed a significantly lower response to NMDA receptor stimulation, reduction of NOS activity and decreased levels of nitrites and nitrates in striatum. These markers of NO function were accompanied by significantly higher levels of LPx and ROS production. These results provide evidence of NO dysfunction in the rat brain associated with arsenic exposure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.