ArticleJournal of neurophysiology2006
Different serotonin receptor agonists have distinct effects on sound-evoked responses in inferior colliculus.
Article in Journal of neurophysiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 47 citations in OpenAlex.
- Moving beyond 5-HTPsychopharmacology · 2026Article
- Distribution of Metabotropic Serotonin Receptors in GABAergic and Glutamatergic Neurons in the Auditory Midbrain.The Journal of comparative neurology · 2026Article
- Acute administration of NLX-101, a Serotonin 1A receptor agonist, improves auditory temporal processing during development in a mouse model of Fragile X Syndrome.Journal of neurodevelopmental disorders · 2025Article
- Altered brain serotonin 5-HTNeuropharmacology · 2024Article
- Listening to your partner: serotonin increases male responsiveness to female vocal signals in mice.Frontiers in human neuroscience · 2023Article
- 5-HT1A Receptors Alter Temporal Responses to Broadband Vocalizations in the Mouse Inferior Colliculus Through Response Suppression.Frontiers in neural circuits · 2021Article
- Acute DOB and PMA Administration Impairs Motor and Sensorimotor Responses in Mice and Causes Hallucinogenic Effects in Adult Zebrafish.Brain sciences · 2020Article
- The Inferior Colliculus in Alcoholism and Beyond.Frontiers in systems neuroscience · 2020Review
- Serotonin 2A Receptor Signaling Underlies LSD-induced Alteration of the Neural Response to Dynamic Changes in Music.Cerebral cortex (New York, N.Y. : 1991) · 2018Article
- Putting it in Context: Linking Auditory Processing with Social Behavior Circuits in the Vertebrate Brain.Integrative and comparative biology · 2017Review
- Serotonin modulates response properties of neurons in the dorsal cochlear nucleus of the mouse.Hearing research · 2017Article
- Serotonin, estrus, and social context influence c-Fos immunoreactivity in the inferior colliculus.Behavioral neuroscience · 2016Article
- Socially induced serotonergic fluctuations in the male auditory midbrain correlate with female behavior during courtship.Journal of neurophysiology · 2016Article
- Long-Lasting Sound-Evoked Afterdischarge in the Auditory Midbrain.Scientific reports · 2016Article
- Acoustic trauma triggers upregulation of serotonin receptor genes.Hearing research · 2014Article
- The dominant role of inhibition in creating response selectivities for communication calls in the brainstem auditory system.Hearing research · 2013Review
- Comodulation of dopamine and serotonin on prefrontal cortical rhythms: a theoretical study.Frontiers in integrative neuroscience · 2013Article
- From behavioral context to receptors: serotonergic modulatory pathways in the IC.Frontiers in neural circuits · 2012Article
- Plasticity of serotonergic innervation of the inferior colliculus in mice following acoustic trauma.Hearing research · 2012Article
- Context-dependent modulation of auditory processing by serotonin.Hearing research · 2011Review
Corrections and comments
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1 author at 1 institution in 1 country.
Funding
Abstract
The neuromodulator serotonin has a complex set of effects on the auditory responses of neurons within the inferior colliculus (IC), a midbrain auditory nucleus that integrates a wide range of inputs from auditory and nonauditory sources. To determine whether activation of different types of serotonin receptors is a source of the variability in serotonergic effects, four selective agonists of serotonin receptors in the serotonin (5-HT) 1 and 5-HT2 families were iontophoretically applied to IC neurons, which were monitored for changes in their responses to auditory stimuli. Different agonists had different effects on neural responses. The 5-HT1A agonist had mixed facilitatory and depressive effects, whereas 5-HT1B and 5-HT2C agonists were both largely facilitatory. Different agonists changed threshold and frequency tuning in ways that reflected their effects on spike count. When pairs of agonists were applied sequentially to the same neurons, selective agonists sometimes affected neurons in ways that were similar to serotonin, but not to other selective agonists tested. Different agonists also differentially affected groups of neurons classified by the shapes of their frequency-tuning curves, with serotonin and the 5-HT1 receptors affecting proportionally more non-V-type neurons relative to the other agonists tested. In all, evidence suggests that the diversity of serotonin receptor subtypes in the IC is likely to account for at least some of the variability of the effects of serotonin and that receptor subtypes fulfill specialized roles in auditory processing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.