ArticleAmerican journal of physiology. Cell physiology2007
Potentiation of insulin-stimulated glucose transport by the AMP-activated protein kinase.
Article in American journal of physiology. Cell physiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 46 citations in OpenAlex.
- A Function-Centric Framework for Mitochondrial Quality Control.Biomolecules · 2026Review
- Role of Skeletal Muscle in Insulin Resistance and Glucose Uptake.Comprehensive Physiology · 2020Review
- Mitochondrial Dysfunction in Age-Related Metabolic Disorders.Proteomics · 2020Review
- Supplementation of scopoletin improves insulin sensitivity by attenuating the derangements of insulin signaling through AMPK.Molecular and cellular biochemistry · 2019Article
- Vav3, a GEF for RhoA, Plays a Critical Role under High Glucose Conditions.Endocrinology and metabolism (Seoul, Korea) · 2014Article
- Mutation in the γ2-subunit of AMP-activated protein kinase stimulates cardiomyocyte proliferation and hypertrophy independent of glycogen storage.Circulation research · 2014Article
- AMPK and Exercise: Glucose Uptake and Insulin Sensitivity.Diabetes & metabolism journal · 2013Article
- Dietary Aloe QDM Complex Reduces Obesity-Induced Insulin Resistance and Adipogenesis in Obese Mice Fed a High-Fat Diet.Immune network · 2012Article
- Recent progress toward understanding the molecular mechanisms that regulate skeletal muscle mass.Cellular signalling · 2011Review
- Novel liver-specific cholic acid-cytarabine conjugates with potent antitumor activities: Synthesis and biological characterization.Acta pharmacologica Sinica · 2011Article
- Dietary Aloe Reduces Adipogenesis via the Activation of AMPK and Suppresses Obesity-related Inflammation in Obese Mice.Immune network · 2011Article
- A role for AMPK in increased insulin action after serum starvation.American journal of physiology. Cell physiology · 2010Article
- Role of ataxia telangiectasia mutated in insulin signalling of muscle-derived cell lines and mouse soleus.Acta physiologica (Oxford, England) · 2010Article
- Deficiency of phosphoinositide 3-kinase enhancer protects mice from diet-induced obesity and insulin resistance.Diabetes · 2010Article
- Lipid-induced mTOR activation in rat skeletal muscle reversed by exercise and 5'-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside.The Journal of endocrinology · 2009Article
- Skeletal muscle insulin resistance: roles of fatty acid metabolism and exercise.Physical therapy · 2008Review
- Crosstalk between the AMP-activated kinase and insulin signaling pathways rescues murine blastocyst cells from insulin resistance.Reproduction (Cambridge, England) · 2008Article
- AICAR induces phosphorylation of AMPK in an ATM-dependent, LKB1-independent manner.Molecular and cellular biochemistry · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Data from the use of activators and inhibitors of the AMP-activated protein kinase (AMPK) suggest that AMPK increases sensitivity of glucose transport to stimulation by insulin in muscle cells. We assayed insulin action after adenoviral (Ad) transduction of constitutively active (CA; a truncated form of AMPKalpha(1)) and dominant-negative (DN; which depletes endogenous AMPKalpha) forms of AMPKalpha (Ad-AMPKalpha-CA and Ad-AMPKalpha-DN, respectively) into C(2)C(12) myotubes. Compared with control (Ad-green fluorescent protein), Ad-AMPK-CA increased the ability of insulin to stimulate glucose transport. The increased insulin action in cells expressing AMPK-CA was suppressed by compound C (an AMPK inhibitor). Exposure of cells to 5-aminoimidazole-4-carboxamide-1beta-D-ribofuranoside (an AMPK activator) increased insulin action in uninfected myotubes and myotubes transduced with green fluorescent protein but not in Ad-AMPK-DN-infected myotubes. In Ad-AMPK-CA-transduced cells, serine phosphorylation of insulin receptor substrate 1 was decreased at a mammalian target of rapamycin (or p70 S6 kinase) target site that has been reported to be associated with insulin resistance. These data suggest that, in myotubes, activated AMPKalpha(1) is sufficient to increase insulin action and that the presence of functional AMPKalpha is required for 5-aminoimidazole-4-carboxamide-1beta,D-ribofuranoside-related increases in insulin action.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.