ArticleAntimicrobial agents and chemotherapy2006
Development of an orogastrointestinal mucosal model of candidiasis with dissemination to visceral organs.
Article in Antimicrobial agents and chemotherapy, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 39 citations in OpenAlex.
- From Oral Candidiasis to Candidemia: A Review of Superficial to Invasive Progression.MicrobiologyOpen · 2026Review
- Synergy In Vitro of Nikkomycin Z with Azole Against the Invasive Form of Candida albicans.Mycopathologia · 2023Article
- Characterization of the Effects of Candida Gastrointestinal Colonization on Clostridioides difficile Infection in a Murine Model.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Comparative Analysis of the Fitness of Candida albicans Strains During Colonization of the Mice Gastrointestinal Tract.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Article
- Virulence assessment of six major pathogenic Candida species in the mouse model of invasive candidiasis caused by fungal translocation.Scientific reports · 2020Article
- Candida albicans induces mucosal bacterial dysbiosis that promotes invasive infection.PLoS pathogens · 2019Article
- "Tissue barriers · 2019Review
- Adaptation ofCurrent clinical microbiology reports · 2018Article
- Rodent Models of Invasive Aspergillosis due toFrontiers in microbiology · 2017Review
- Candida albicans Pathogenesis: Fitting within the Host-Microbe Damage Response Framework.Infection and immunity · 2016Review
- New insights into innate immune control of systemic candidiasis.Medical mycology · 2014Review
- Innocent until proven guilty: mechanisms and roles of Streptococcus-Candida interactions in oral health and disease.Molecular oral microbiology · 2014Review
- Article
- Murine models of Candida gastrointestinal colonization and dissemination.Eukaryotic cell · 2013Review
- Hosting infection: experimental models to assay Candida virulence.International journal of microbiology · 2012Article
- The role of the IL-12 cytokine family in directing T-cell responses in oral candidosis.Clinical & developmental immunology · 2011Review
- A novel immunocompetent murine model for Candida albicans-promoted oral epithelial dysplasia.Medical mycology · 2009Article
- Animal models of mucosal Candida infection.FEMS microbiology letters · 2008Review
- Mucosal damage and neutropenia are required for Candida albicans dissemination.PLoS pathogens · 2008Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Studies were done to develop a murine model that mimics the pattern of mucosal candidiasis followed by disseminated disease seen in patients given cytotoxic chemotherapy. Developmental studies showed that suppression of mice with 5-fluorouracil beginning 3 days prior to infection and given every 7 days thereafter necessitated antibacterial treatment but resulted in a reproducible model. Candida albicans given in the drinking water resulted in oral infection by day 3 that significantly increased from days 10 to 15 and mucosal infection with 4 to 7 log(10) Candida CFU in the esophagus, stomach, small intestine, and cecum. Dissemination to livers occurred and was 100% on days 5 to 15; fewer animals had kidney infection. The median kidney or liver CFU were 2 or 3 log(10) CFU, respectively, on day 15; despite this, mortality was low through 21 days of infection. As a demonstration of the utility of the model to test antifungal activity, daily treatment with 10 or 50 mg/kg itraconazole significantly reduced dissemination to the liver and kidneys and reduced tongue CFU compared to controls. Overall, these studies indicate that a nonlethal model of oral and gastrointestinal mucosal candidiasis with dissemination can be established in mice. Drug efficacy in treating localized infection and in preventing or treating disseminated infection can be studied.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.