ArticleAntimicrobial agents and chemotherapy2006
Comparative analysis of sequences flanking tet(W) resistance genes in multiple species of gut bacteria.
Article in Antimicrobial agents and chemotherapy, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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54 citing papers in PubMed.
- Endogenous CRISPR-Based Removal of Tetracycline Resistance in Bifidobacterium animalis subsp. lactis Through a Safe-by-Design Approach.Microbial biotechnology · 2026Article
- IME_Rho_tet, a novel family of putative integrative mobilizable elements spreading tetracycline resistance genesMicrobial genomics · 2026Article
- Coccidiosis prevention strategies shape the microbiome, resistome and mobilome composition in the broiler gut.Animal microbiome · 2026Article
- Novel insights into carbohydrate utilisation, antimicrobial resistance, and sporulation potential inGut microbes · 2025Article
- Exploring the Potential Probiotic Properties of Bifidobacterium breve DSM 32583-A Novel Strain Isolated from Human Milk.Probiotics and antimicrobial proteins · 2025Article
- Prevalence of Antibiotic-Resistant Lactobacilli in Sepsis Patients with Long-Term Antibiotic Therapy.Current microbiology · 2022Article
- Studies on the Transmission of a Tigecycline Resistance-MediatingMicrobiology spectrum · 2022Article
- Genome analysis of probiotic bacteria for antibiotic resistance genes.Antonie van Leeuwenhoek · 2022Article
- Exploring the Genomic Diversity and Antimicrobial Susceptibility of Bifidobacterium pseudocatenulatum in a Vietnamese Population.Microbiology spectrum · 2021Article
- Xylan utilisation promotes adaptation of Bifidobacterium pseudocatenulatum to the human gastrointestinal tract.ISME communications · 2021Article
- Mobile Antimicrobial Resistance Genes in Probiotics.Antibiotics (Basel, Switzerland) · 2021Article
- PathFams: statistical detection of pathogen-associated protein domains.BMC genomics · 2021Article
- Article
- Investigation of the Prevalence of Antibiotic Resistance Genes According to the Wastewater Treatment Scale Using Metagenomic Analysis.Antibiotics (Basel, Switzerland) · 2021Article
- The distribution of antibiotic resistance genes in chicken gut microbiota commensals.Scientific reports · 2021Article
- The Tetracycline Resistance Gene,Frontiers in microbiology · 2021Article
- Literature-Based Phenotype Survey and In Silico Genotype Investigation of Antibiotic Resistance in the Genus Bifidobacterium.Current microbiology · 2020Article
- Dietary supplementation of Neem (Veterinary world · 2020Article
- Transferable Resistance GeneAntimicrobial agents and chemotherapy · 2020Article
- Environmental Impact on Differential Composition of Gut Microbiota in Indoor Chickens in Commercial Production and Outdoor, Backyard Chickens.Microorganisms · 2020Article
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3 authors.
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Abstract
tet(W) is one of the most abundant tetracycline resistance genes found in bacteria from the mammalian gut and was first identified in the rumen anaerobe Butyrivibrio fibrisolvens 1.230, where it is highly mobile and its transfer is associated with the transposable chromosomal element TnB1230. In order to compare the genetic basis for tet(W) carriage in different bacteria, we studied sequences flanking tet(W) in representatives of seven bacterial genera originating in diverse gut environments. The sequences 657 bp upstream and 43 bp downstream of tet(W) were 96 to 100% similar in all strains examined. A common open reading frame (ORF) was identified downstream of tet(W) in five different bacteria, while another conserved ORF that flanked tet(W) in B. fibrisolvens 1.230 was also present upstream of tet(W) in a human colonic Roseburia isolate and in another rumen B. fibrisolvens isolate. In one species, Bifidobacterium longum (strain F8), a novel transposase was located within the conserved 657-bp region upstream of tet(W) and was flanked by imperfect direct repeats. Additional direct repeats 6 bp long were identified on each end of a chromosomal ORF interrupted by the insertion of the putative transposase and the tet(W) gene. This tet(W) gene was transferable at low frequencies between Bifidobacterium strains. A putative minielement carrying a copy of tet(W) was identified in B. fibrisolvens transconjugants that had acquired the tet(W) gene on TnB1230. Several different mechanisms, including mechanisms involving plasmids and conjugative transposons, appear to be involved in the horizontal transfer of tet(W) genes, but small core regions that may function as minielements are conserved.
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