Evidence map›Paper›PMID 16870722›Full record

ArticleNucleic acids research2006

Nearest neighbor parameters for Watson-Crick complementary heteroduplexes formed between 2'-O-methyl RNA and RNA oligonucleotides.

Elzbieta Kierzek, David H Mathews, Anna Ciesielska, Douglas H Turner, Ryszard Kierzek

Abstract read
In one paragraph

Article in Nucleic acids research, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Article
  2. ASOG: AntiSense Oligonucleotide Generator.Computational and structural biotechnology journal · 2025
    Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Elzbieta KierzekDepartment of Chemistry, University of Rochester, RC Box 270216, Rochester, NY 14627, USA.
David H Mathews
Anna Ciesielska
Douglas H Turner
Ryszard Kierzek

Funding

KINETIC AND SPECTROSCOPIC STUDIES OF NUCLEIC ACIDSR01GM022939 · NIGMS · UNIVERSITY OF ROCHESTER · PI TURNER, DOUGLAS H. · 1985 to 2016
$7.6M
FOLDING RNA WITH MODIFIED OLIGONUCLEOTIDESR03TW001068 · FIC · UNIVERSITY OF ROCHESTER · PI TURNER, DOUGLAS H. · 1999 to 2004
$192k
FIC NIH HHS 1R03 TW1068FIC NIH HHS R03 TW001068NIGMS NIH HHS GM22939NIGMS NIH HHS R01 GM022939
6 · The paper itself

Abstract

Results from optical melting studies of Watson-Crick complementary heteroduplexes formed between 2'-O-methyl RNA and RNA oligonucleotides are used to determine nearest neighbor thermodynamic parameters for predicting the stabilities of such duplexes. The results are consistent with the physical model assumed by the individual nearest neighbor-hydrogen bonding model, which contains terms for helix initiation, base pair stacking and base pair composition. The sequence dependence is similar to that for Watson-Crick complementary RNA/RNA duplexes, which suggests that the sequence dependence may also be similar to that for other backbones that favor A-form RNA conformations.

Indexed as

ThermodynamicsBase PairingMethylationOligoribonucleotidesRNA, Double-StrandedOligoribonucleotidesRNA, Double-Stranded

Identifiers

PMID16870722
PMCPMC1540717

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.