ArticleMolecular biology of the cell2006
Novel function of clathrin light chain in promoting endocytic vesicle formation.
Article in Molecular biology of the cell, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 46 citations in OpenAlex.
- Clathrin light chains CLCa and CLCb have non-redundant roles in epithelial lumen formation.Life science alliance · 2024Article
- Taming the Triskelion: Bacterial Manipulation of Clathrin.Microbiology and molecular biology reviews : MMBR · 2019Review
- Identification of Suppressor of Clathrin Deficiency-1 (G3 (Bethesda, Md.) · 2019Article
- A role for the yeast CLIP170 ortholog, the plus-end-tracking protein Bik1, and the Rho1 GTPase in Snc1 trafficking.Journal of cell science · 2016Article
- Clathrin light chains' role in selective endocytosis influences antibody isotype switching.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Creating a chimeric clathrin heavy chain that functions independently of yeast clathrin light chain.Traffic (Copenhagen, Denmark) · 2016Article
- Article
- Molecular structure, function, and dynamics of clathrin-mediated membrane traffic.Cold Spring Harbor perspectives in biology · 2014Review
- Clathrin light chains regulate clathrin-mediated trafficking, auxin signaling, and development in Arabidopsis.The Plant cell · 2013Article
- Nuclear localization of clathrin involves a labile helix outside the trimerization domain.FEBS letters · 2013Article
- Regulation of cell wall synthesis by the clathrin light chain is essential for viability in Schizosaccharomyces pombe.PloS one · 2013Article
- Structural disorder provides increased adaptability for vesicle trafficking pathways.PLoS computational biology · 2013Article
- A common clathrin-mediated machinery co-ordinates cell-cell adhesion and bacterial internalization.Traffic (Copenhagen, Denmark) · 2012Article
- Ultrastructural dynamics of proteins involved in endocytic budding.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Analysis of yeast endocytic site formation and maturation through a regulatory transition point.Molecular biology of the cell · 2012Article
- Clathrin-mediated endocytosis in budding yeast.Trends in cell biology · 2012Review
- Lessons from yeast for clathrin-mediated endocytosis.Nature cell biology · 2011Review
- Clathrin light chain directs endocytosis by influencing the binding of the yeast Hip1R homologue, Sla2, to F-actin.Molecular biology of the cell · 2011Article
- Quantitative analysis of the mechanism of endocytic actin patch assembly and disassembly in fission yeast.Molecular biology of the cell · 2010Article
- HIP1 exhibits an early recruitment and a late stage function in the maturation of coated pits.Cellular and molecular life sciences : CMLS · 2009Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Clathrin-mediated endocytosis is a major pathway for uptake of lipid and protein cargo at the plasma membrane. The lattices of clathrin-coated pits and vesicles are comprised of triskelions, each consisting of three oligomerized heavy chains (HC) bound by a light chain (LC). In addition to binding HC, LC interacts with members of the Hip1/R family of endocytic proteins, including the budding yeast homologue, Sla2p. Here, using in vivo analysis in yeast, we provide novel insight into the role of this interaction. We find that overexpression of LC partially restores endocytosis to cells lacking clathrin HC. This suppression is dependent on the Sla2p binding region of LC. Using live cell imaging techniques to visualize endocytic vesicle formation, we find that the N-terminal Sla2p binding region of LC promotes the progression of arrested Sla2p patches that form in the absence of HC. We propose that LC binding to Sla2p positively regulates Sla2p for efficient endocytic vesicle formation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.