Trial reportDigestive diseases and sciences2006
The efficacy of an herbal medicine, Carmint, on the relief of abdominal pain and bloating in patients with irritable bowel syndrome: a pilot study.
Trial report in Digestive diseases and sciences, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 77 citations in OpenAlex.
- Systematic Review and Meta-Analysis: Plant-Based Therapy for Irritable Bowel Syndrome.Phytotherapy research : PTR · 2026Pooled it
- Potential Benefit With Complementary and Alternative Medicine in Irritable Bowel Syndrome: A Systematic Review and Meta-analysis.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2021Pooled it
- Herbal medicines for the management of irritable bowel syndrome: a comprehensive review.World journal of gastroenterology · 2012Pooled it
- Effect of herbal formula based on rosa damascena on functional bloating severity in older adults: a pilot double-blind randomized controlled trial.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2026Trial
- Investigating the Health Potential ofPharmaceuticals (Basel, Switzerland) · 2025Review
- Efficacy of Jawarish Shahi a herbal formulation in irritable bowel syndrome: An open-labeled single-arm clinical trial.Journal of traditional and complementary medicine · 2022Article
- Development and validation of the Health Promoting Behaviour for Bloating (HPB-Bloat) scale.PeerJ · 2021Article
- Article
- Reduction of Inflammation and Colon Injury by a Spearmint Phenolic Extract in Experimental Bowel Disease in Mice.Medicines (Basel, Switzerland) · 2019Article
- Probiotics, fibre and herbal medicinal products for functional and inflammatory bowel disorders.British journal of pharmacology · 2017Review
- Evaluating the efficacy of mixture ofJournal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2017Article
- Herbal Medicines for the Management of Irritable Bowel Syndrome: A Systematic Review.Electronic physician · 2016Article
- Antinociceptive and antihyperglycemic effects of Melissa officinalis essential oil in an experimental model of diabetes.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2015Article
- Assessment of Lemon Balm (Melissa officinalis L.) Hydrogels: Quality and Bioactivity in Skin Cells.Evidence-based complementary and alternative medicine : eCAM · 2015Article
- Evaluation of possible toxic effects of spearmint (Mentha spicata) on the reproductive system, fertility and number of offspring in adult male rats.Avicenna journal of phytomedicine · 2014Article
- Comparison of the antibacterial activity of essential oils and extracts of medicinal and culinary herbs to investigate potential new treatments for irritable bowel syndrome.BMC complementary and alternative medicine · 2013Article
- Effect of korean herbal medicine combined with a probiotic mixture on diarrhea-dominant irritable bowel syndrome: a double-blind, randomized, placebo-controlled trial.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Anti-anxiety activity of Coriandrum sativum assessed using different experimental anxiety models.Indian journal of pharmacology · 2011Article
- Irritable bowel syndrome: a review article.Middle East journal of digestive diseases · 2010Review
- The treatment of irritable bowel syndrome.Therapeutic advances in gastroenterology · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Carmint contains total extracts of Melissa officinalis, Mentha spicata, and Coriandrum sativum, which have antispasmodic, carminative, and sedative effects. As abdominal pain/discomfort and bloating are commonly observed in patients with irritable bowel syndrome, we decided to evaluate the effectiveness of Carmint in relieving these symptoms in irritable bowel syndrome patients. We randomly assigned 32 irritable bowel syndrome patients to receive either Carmint or placebo, plus Loperamide or psyllium (based on their predominant bowel function), for 8 weeks. T-test analysis of the results showed that the severity and frequency of abdominal pain/discomfort were significantly lower in the Carmint group than the placebo group at the end of the treatment (P=0.016 and P=0.001, respectively), as were the severity and frequency of bloating (P=0.02 and P=0.002, respectively). This pilot study suggests that Carmint plus loperamide or Carmint plus psyllium (depending on the irritable bowel syndrome subtype) might be effective in these patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.