ReviewJournal of gastroenterology2006
Therapeutic strategies for functional dyspepsia and the introduction of the Rome III classification.
Review in Journal of gastroenterology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01591174 (Evaluation of Liquid Gastric Emptying and Plasma Ghrelin in Children With Functional Dyspepsia), which is not on this map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of Liquid Gastric Emptying and Plasma Ghrelin in Children With Functional Dyspepsia
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.
- Itopride therapy for functional dyspepsia: a meta-analysis.World journal of gastroenterology · 2012Pooled it
- Ecabet sodium induces neuronal nitric oxide synthase-derived nitric oxide synthesis and gastric adaptive relaxation in the human stomach.Journal of gastroenterology · 2009Trial
- It is possible to classify non-erosive reflux disease (NERD) patients into endoscopically normal groups and minimal change groups by subjective symptoms and responsiveness to rabeprazole -- a report from a study with Japanese patients.Digestive diseases and sciences · 2008Trial
- Role of Gut Microbiota-Gut Hormone Axis in the Pathophysiology of Functional Gastrointestinal Disorders.Journal of neurogastroenterology and motility · 2018Review
- The Pharmacological Effects of Benachio-F(®) on Rat Gastrointestinal Functions.Biomolecules & therapeutics · 2015Article
- Efficacy and tolerability of levosulipride, domperidone and metoclopramide in patients with non-ulcer functional dyspepsia: a comparative analysis.Journal of clinical and diagnostic research : JCDR · 2015Article
- Effect of lansoprazole on the epigastric symptoms of functional dyspepsia (ELF study): A multicentre, prospective, randomized, double-blind, placebo-controlled clinical trial.United European gastroenterology journal · 2013Article
- DA-9701: A New Multi-Acting Drug for the Treatment of Functional Dyspepsia.Biomolecules & therapeutics · 2013Review
- Helicobacter pylori infection in functional dyspepsia.Nature reviews. Gastroenterology & hepatology · 2013Review
- Transmural pressure loading enhances gastric mucosal cell proliferation.Digestive diseases and sciences · 2012Article
- Proton pump inhibitor-amoxicillin-clarithromycin versus proton pump inhibitor-amoxicillin-metronidazole as first-line Helicobacter pylori eradication therapy.Journal of clinical biochemistry and nutrition · 2012Article
- Dual therapy for third-line Helicobacter pylori eradication and urea breath test prediction.World journal of gastroenterology · 2012Article
- Itopride in the treatment of functional dyspepsia in Chinese patients: a prospective, multicentre, post-marketing observational study.Clinical drug investigation · 2011Article
- Overlap syndrome of functional dyspepsia and irritable bowel syndrome - are both diseases mutually exclusive?Journal of neurogastroenterology and motility · 2011Article
- Proton-pump inhibitors for the treatment of functional dyspepsia.Therapeutic advances in gastroenterology · 2011Article
- What is the difference between Helicobacter pylori-associated dyspepsia and functional dyspepsia?Journal of neurogastroenterology and motility · 2011Article
- The Traditional Japanese Medicine Rikkunshito Promotes Gastric Emptying via the Antagonistic Action of the 5-HT(3) Receptor Pathway in Rats.Evidence-based complementary and alternative medicine : eCAM · 2011Article
- The effect of traditional Japanese medicine (Kampo) on gastrointestinal function.Surgery today · 2010Article
- Interactions of gastrointestinal peptides: ghrelin and its anorexigenic antagonists.International journal of peptides · 2010Article
- Ghrelin and functional dyspepsia.International journal of peptides · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although placebo response rates in clinical trials for functional dyspepsia (FD) are more than 30%, a recent meta-analysis based on randomized controlled trials (RCTs) showed that antisecretory drugs were more or less superior to placebos. On the other hand, large-scale RCTs on the efficacy of treatment with prokinetics on FD are still needed. Indications for antibiotic eradication therapy for Helicobacter pylori-positive FD are still controversial, but there seems to be a small but significant therapeutic gain achieved with H. pylori eradication. Since preprandial and postprandial symptomatic disturbances are very important targets for FD treatment, ghrelin, a novel appetite-promoting gastrointestinal peptide that also promotes gastric motility or basal acid secretion can be expected to be a therapeutic target. In the recently published Rome III classification, FD is redefined for patients with symptoms thought to originate from the gastroduodenal region, specifically epigastric pain or burning, postprandial fullness, or early satiation, and it is divided into the subcategories postprandial distress syndrome and epigastric pain syndrome. These new criteria are of value in clinical practice, for epidemiological, pathophysiological, and clinical research, and for the development of new therapeutic strategies.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.