ArticlePflugers Archiv : European journal of physiology2006
Impact of post-synaptic block of neuromuscular transmission, muscle unloading and mechanical ventilation on skeletal muscle protein and mRNA expression.
Article in Pflugers Archiv : European journal of physiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 47 citations in OpenAlex.
- Mitochondrial Dysfunction in Intensive Care Unit-Acquired Weakness and Critical Illness Myopathy: A Narrative Review.International journal of molecular sciences · 2023Review
- Single fibre cytoarchitecture in ventilator-induced diaphragm dysfunction (VIDD) assessed by quantitative morphometry second harmonic generation imaging: Positive effects of BGP-15 chaperone co-inducer and VBP-15 dissociative corticosteroid treatment.Frontiers in physiology · 2023Article
- Identification of feature genes and key biological pathways in immune-mediated necrotizing myopathy: High-throughput sequencing and bioinformatics analysis.Computational and structural biotechnology journal · 2023Article
- A prospective clinical study on the mechanisms underlying critical illness myopathy-A time-course approach.Journal of cachexia, sarcopenia and muscle · 2022Article
- Metabolomic Profiling of Respiratory Muscles and Lung in Response to Long-Term Controlled Mechanical Ventilation.Frontiers in cell and developmental biology · 2022Article
- Neurogenic vs. Myogenic Origin of Acquired Muscle Paralysis in Intensive Care Unit (ICU) Patients: Evaluation of Different Diagnostic Methods.Diagnostics (Basel, Switzerland) · 2020Article
- Intensive Care Unit-Acquired Weakness: Not just Another Muscle Atrophying Condition.International journal of molecular sciences · 2020Review
- Does prolonged propofol sedation of mechanically ventilated COVID-19 patients contribute to critical illness myopathy?British journal of anaesthesia · 2020Article
- Chaperone co-inducer BGP-15 mitigates early contractile dysfunction of the soleus muscle in a rat ICU model.Acta physiologica (Oxford, England) · 2020Article
- Impaired Ca(2+) release contributes to muscle weakness in a rat model of critical illness myopathy.Critical care (London, England) · 2016Article
- Mechanical Signaling in the Pathophysiology of Critical Illness Myopathy.Frontiers in physiology · 2016Review
- The Sick and the Weak: Neuropathies/Myopathies in the Critically Ill.Physiological reviews · 2015Review
- Time course analysis of mechanical ventilation-induced diaphragm contractile muscle dysfunction in the rat.The Journal of physiology · 2014Article
- The Effect of Nutritional Status in the Pathogenesis of Critical Illness Myopathy (CIM).Biology · 2014Article
- Masseter muscle myofibrillar protein synthesis and degradation in an experimental critical illness myopathy model.PloS one · 2014Article
- Sparing of muscle mass and function by passive loading in an experimental intensive care unit model.The Journal of physiology · 2013Article
- Mechanisms underlying ICU muscle wasting and effects of passive mechanical loading.Critical care (London, England) · 2012Article
- Muscle wasting in animal models of severe illness.International journal of experimental pathology · 2012Review
- Muscle wasting and the temporal gene expression pattern in a novel rat intensive care unit model.BMC genomics · 2011Article
- Upregulation of the CaV 1.1-ryanodine receptor complex in a rat model of critical illness myopathy.American journal of physiology. Regulatory, integrative and comparative physiology · 2011Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
To analyse mechanisms of muscle wasting in intensive care unit patients, we developed an experimental model where rats were pharmacologically paralysed by post-synaptic block of neuromuscular transmission (NMB) and mechanically ventilated for 9+/-2 days. Specific interest was focused on the effects on protein and mRNA expression of sarcomeric proteins, i.e., myosin heavy chain (MyHC), actin, myosin-binding protein C (MyBP-C) and myosin-binding protein H (MyBP-H) in fast- and slow-twitch limb, respiratory and masticatory muscles. Muscle-specific differences were observed in response to NMB at both the protein and mRNA levels. At the protein level, a decreased MyHC-to-actin ratio was observed in all muscles excluding the diaphragm, whereas at the mRNA level a decreased expression of the dominating MyHC isoform(s) was observed in the hind limb and intercostal muscles, but not in the diaphragm and masseter muscles. MyBP-C mRNA expression was decreased in the limb muscles, but it otherwise remained unaffected. MyBP-H conversely increased in all muscles. Furthermore, we found myofibrillar protein and mRNA expression to be affected differently when comparing NMB animals with peripherally denervated (DEN) ambulatory rats. We report that NMB has both a larger and different impact on muscle, at the protein and mRNA levels, than DEN has.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.