ArticleThe Journal of membrane biology2006
AQP and the control of fluid transport in a salivary gland.
Article in The Journal of membrane biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
21 citing papers in PubMed, 57 citations in OpenAlex.
- Dietary fatty acids and the time elapsed from their intake are related to their composition in rat submandibular gland and salivary flow rates.Clinical oral investigations · 2020Article
- Article
- Aquaporins in Health and Disease: An Overview Focusing on the Gut of Different Species.International journal of molecular sciences · 2016Review
- Physiological role of aquaporin 5 in salivary glands.Pflugers Archiv : European journal of physiology · 2016Review
- Aquaporins in Salivary Glands: From Basic Research to Clinical Applications.International journal of molecular sciences · 2016Review
- Mechanism involved in Danshen-induced fluid secretion in salivary glands.World journal of gastroenterology · 2015Article
- Ca²⁺-dependent K⁺ channels in exocrine salivary glands.Cell calcium · 2014Review
- New insights of aquaporin 5 in the pathogenesis of high altitude pulmonary edema.Diagnostic pathology · 2013Article
- Mercury-sensitive water channels as possible sensors of water potentials in pollen.Journal of experimental botany · 2013Article
- Implantable three-dimensional salivary spheroid assemblies demonstrate fluid and protein secretory responses to neurotransmitters.Tissue engineering. Part A · 2013Article
- Roles of AQP5/AQP5-G103D in carbamylcholine-induced volume decrease and in reduction of the activation energy for water transport by rat parotid acinar cells.Pflugers Archiv : European journal of physiology · 2012Article
- Molecular mechanism of pancreatic and salivary gland fluid and HCO3 secretion.Physiological reviews · 2012Review
- Localization of AQP5 during development of the mouse submandibular salivary gland.Journal of molecular histology · 2011Article
- Cotransport of water by the Na+-K+-2Cl(-) cotransporter NKCC1 in mammalian epithelial cells.The Journal of physiology · 2010Article
- Water-transporting proteins.The Journal of membrane biology · 2010Review
- Dynamic regulation of barrier integrity of the corneal endothelium.Optometry and vision science : official publication of the American Academy of Optometry · 2010Review
- Frequency spectrum of transepithelial potential difference reveals transport-related oscillations.Biophysical journal · 2009Article
- Fluid transport: a guide for the perplexed.The Journal of membrane biology · 2008Review
- Interaction between transcellular and paracellular water transport pathways through Aquaporin 5 and the tight junction complex.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Secretion and fluid transport mechanisms in the mammary gland: comparisons with the exocrine pancreas and the salivary gland.Journal of mammary gland biology and neoplasia · 2006Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Experiments were performed with the perfused rat submandibular gland in vitro to investigate the nature of the coupling between transported salt and water by varying the osmolarity of the source bath and observing the changes in secretory volume flow. Glands were submitted to hypertonic step changes by changing the saline perfusate to one containing different levels of sucrose. The flow rate responded by falling to a lower value, establishing a new steady-state flow. The rate changes did not correspond to those expected from a system in which fluid production is due to simple osmotic equilibration, but were much larger. The changes were fitted to a model in which fluid production is largely paracellular, the rate of which is controlled by an osmosensor system in the basal membrane. The same experiments were done with glands from rats that had been bred to have very low levels of AQP5 (the principal aquaporin of the salivary acinar cell) in which little AQP5 is expressed at the basal membrane. In these rats, salivary secretion rates after hypertonic challenges were small and best modelled by simple osmotic equilibration. In rats which had intermediate AQP5 levels the changes in flow rate were similar to those of normal rats although their AQP5 levels were reduced.Finally, perfused normal glands were subject to retrograde ductal injection of salines containing different levels of Hg(2+) ions (0, 10 and 100 microM: ) which would act as inhibitors of AQP5 at the apical acinar membrane. The overall flow rates were progressively diminished with rising Hg(2+) concentration, but after hypertonic challenge the changes in flow rates were unchanged and similar to those of normal rats. All these results are difficult to explain by a cellular osmotic model but can be explained by a model in which paracellular flow is controlled by an osmosensor (presumably AQP5) present on the basal membrane.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.