ArticleBritish journal of pharmacology1991
Clonidine inhibits ATP-sensitive K+ channels in mouse pancreatic beta-cells.
Article in British journal of pharmacology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 42 citations in OpenAlex.
- Adrenoceptor Expression and Function in the Endocrine Pancreas.Handbook of experimental pharmacology · 2024Review
- Obesity under the moonlight of c-MYC.Frontiers in cell and developmental biology · 2023Review
- Changes of imidazoline receptors in spontaneously hypertensive rats.International journal of experimental pathology · 2013Article
- Effect of clonidine on blood glucose levels in euglycemic and alloxan-induced diabetic rats and its interaction with glibenclamide.Indian journal of pharmacology · 2009Article
- Roles of K+ channels in regulating tumour cell proliferation and apoptosis.Pflugers Archiv : European journal of physiology · 2004Review
- In vitro mechanism of action on insulin release of S-22068, a new putative antidiabetic compound.British journal of pharmacology · 1999Article
- Multiple effects and stimulation of insulin secretion by the tyrosine kinase inhibitor genistein in normal mouse islets.British journal of pharmacology · 1995Article
- Antagonism of levcromakalim by imidazoline- and guanidine-derivatives in rat portal vein: involvement of the delayed rectifier.British journal of pharmacology · 1993Article
- Antagonism of the stimulatory effects of efaroxan and glibenclamide in rat pancreatic islets by the imidazoline, RX801080.British journal of pharmacology · 1993Article
- Stimulation of insulin secretion by imidazoline compounds is not due to interaction with non-adrenoceptor idazoxan binding sites.British journal of pharmacology · 1993Article
- The fiftieth anniversary of hypoglycaemic sulphonamides. How did the mother compound work?Diabetologia · 1992Article
- Imidazoline antagonists of alpha 2-adrenoceptors increase insulin release in vitro by inhibiting ATP-sensitive K+ channels in pancreatic beta-cells.British journal of pharmacology · 1992Article
- The many lives of Myc in the pancreatic β-cell.The Journal of biological chemistryReview
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. The effects of clonidine and adrenaline on adenosine 5'-triphosphate (ATP)-sensitive K+ channels were studied in pancreatic beta-cells from normal mice. 2. When perifused with a medium containing 1 mM glucose, many of the ATP-sensitive K+ channels in the beta-cell membrane are open. Under these conditions, clonidine (5-100 microM) reversibly decreased 86Rb efflux from the islets, whereas adrenaline was ineffective at concentrations up to 100 microM. 3. In 6 mM glucose, most of the ATP-sensitive K+ channels in the beta-cell membrane are closed. Opening these channels by diazoxide (100 microM) caused a marked acceleration of 86Rb efflux from the islets, which was attenuated by 100 microM clonidine. 4. ATP-sensitive K+ currents were measured in single beta-cells by the whole cell mode of the patch-clamp technique. At concentrations above 4 microM, clonidine reversibly inhibited the ATP-sensitive K+ current in a dose-dependent manner. 5. Voltage-sensitive K+ currents were unaffected by 20 microM but decreased slightly by 100 microM clonidine. 6. Calcium currents, measured by the whole cell or perforated patch technique, were unaffected by clonidine at concentrations up to 100 microM. 7. It is concluded that high concentrations of the alpha 2-adrenoceptor agonist clonidine, but not of adrenaline, can inhibit ATP-sensitive K+ channels in pancreatic beta-cells. Other ionic channels are only slightly affected or unaffected.
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