ArticleWorld journal of gastroenterology2006
Role of neuronal nitric oxide synthase and inducible nitric oxide synthase in intestinal injury in neonatal rats.
Article in World journal of gastroenterology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 17 citations in OpenAlex.
- Neuronal Nitric Oxide Synthase (nNOS) in Neutrophils: An Insight.Reviews of physiology, biochemistry and pharmacology · 2021Review
- Article
- Protective effects of oral glutathione on fasting-induced intestinal atrophy through oxidative stress.World journal of gastroenterology · 2017Article
- Inducible and neuronal nitric oxide synthases exert contrasting effects during rat intestinal recovery following fasting.Experimental biology and medicine (Maywood, N.J.) · 2017Article
- Toll-Like Receptor 4 Modulates Small Intestine Neuromuscular Function through Nitrergic and Purinergic Pathways.Frontiers in pharmacology · 2017Article
- Role of cyclooxygenase-2 in intestinal injury in neonatal rats.Biomedical reports · 2014Article
- Enteric nervous system abnormalities are present in human necrotizing enterocolitis: potential neurotransplantation therapy.Stem cell research & therapy · 2013Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the dynamic change and role of neuronal nitric oxide synthase (nNOS) and inducible nitric oxide synthase (iNOS) in neonatal rat with intestinal injury and to define whether necrotizing enterocolitis (NEC) is associated with the levels of nitric oxide synthase (NOS) in the mucosa of the affected intestine tissue.
methodsWistar rats less than 24 h in age received an intraperitoneal injection with 5 mg/kg lipopolysaccharide (LPS). Ileum tissues were collected at 1, 3, 6, 12 and 24 h following LPS challenge for histological evaluation of NEC and for measurements of nNOS and iNOS. The correlation between the degree of intestinal injury and levels of NOS was determined.
resultsThe LPS-injected pups showed a significant increase in injury scores versus the control. The expression of nNOS protein and mRNA was diminished after LPS injection. There was a negative significant correlation between the nNOS protein and the grade of median intestinal injury within 24 h. The expression of iNOS protein and mRNA was significantly increased in the peak of intestinal injury.
conclusionnNOS and iNOS play different roles in LPS-induced intestinal injury. Caution should be exerted concerning potential therapeutic uses of NOS inhibitors in NEC.
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