ReviewWorld journal of gastroenterology2006
Heme in intestinal epithelial cell turnover, differentiation, detoxification, inflammation, carcinogenesis, absorption and motility.
Review in World journal of gastroenterology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 74 citations in OpenAlex.
- Ferroptosis: Biology and Role in Gastrointestinal Disease.Gastroenterology · 2024Review
- Pathological significance of heme oxygenase-1 as a potential tumor promoter in heme-induced colorectal carcinogenesis.Cancer pathogenesis and therapy · 2024Review
- Transferrin Receptor-Mediated Iron Uptake Promotes Colon Tumorigenesis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Alterations in co-abundant bacteriome in colorectal cancer and its persistence after surgery: a pilot study.Scientific reports · 2022Article
- Misexpression of genes lacking CpG islands drives degenerative changes during aging.Science advances · 2021Article
- Low Birth Weight Disturbs the Intestinal Redox Status and Mitochondrial Morphology and Functions in Newborn Piglets.Animals : an open access journal from MDPI · 2021Article
- Hemin Prevents Increased Glycolysis in Macrophages upon Activation: Protection by Microbiota-Derived Metabolites of Polyphenols.Antioxidants (Basel, Switzerland) · 2020Article
- Pro-apoptotic effect of haem oxygenase-1 in human colorectal carcinoma cells via endoplasmic reticular stress.Journal of cellular and molecular medicine · 2019Article
- The interaction of Hemin and Sestrin2 modulates oxidative stress and colon tumor growth.Toxicology and applied pharmacology · 2019Article
- Digit Tip Injuries: Current Treatment and Future Regenerative Paradigms.Stem cells international · 2019Review
- Human regeneration: An achievable goal or a dream?Journal of biosciences · 2016Review
- Protoporphyrin IX catalyzed hydrogen peroxide to generate singlet oxygen.International journal of clinical and experimental medicine · 2015Article
- Interactions between meat intake and genetic variation in relation to colorectal cancer.Genes & nutrition · 2015Article
- Oxidative stress: an essential factor in the pathogenesis of gastrointestinal mucosal diseases.Physiological reviews · 2014Review
- Heme, an essential nutrient from dietary proteins, critically impacts diverse physiological and pathological processes.Nutrients · 2014Review
- Predicting the impact of diet and enzymopathies on human small intestinal epithelial cells.Human molecular genetics · 2013Article
- Regulation of heme oxygenase expression by alcohol, hypoxia and oxidative stress.World journal of biological chemistry · 2011Article
- Heme oxygenase-1 system and gastrointestinal inflammation: a short review.World journal of gastroenterology · 2011Review
- Lack of association between the c.544G>A polymorphism of the heme oxygenase-2 gene and age-related macular degeneration.Medical science monitor : international medical journal of experimental and clinical research · 2011Article
- Nickel(II) chelatase variants directly evolved from murine ferrochelatase: porphyrin distortion and kinetic mechanism.Biochemistry · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The gastrointestinal tract is lined by a simple epithelium that undergoes constant renewal involving cell division, differentiation and cell death. In addition, the epithelial lining separates the hostile processes of digestion and absorption that occur in the intestinal lumen from the aseptic environment of the internal milieu by defensive mechanisms that protect the epithelium from being breached. Central to these defensive processes is the synthesis of heme and its catabolism by heme oxygenase (HO). Dietary heme is also an important source of iron for the body which is taken up intact by the enterocyte. This review describes the recent literature on the diverse properties of heme/HO in the intestine tract. The roles of heme/HO in the regulation of the cell cycle/apoptosis, detoxification of xenobiotics, oxidative stress, inflammation, development of colon cancer, heme-iron absorption and intestinal motility are specifically examined.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.