ArticleDigestive diseases and sciences2006
An animal model of black pigment gallstones caused by nanobacteria.
Article in Digestive diseases and sciences, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 40 citations in OpenAlex.
- Mechanism of influence of calcified nanoparticles in the development of calcified diseases (Review).Biomedical reports · 2025Review
- Surgical treatments for patients with recurrent bile duct stones and Oddis sphincter laxity.Intractable & rare diseases research · 2017Review
- Composition of gallbladder bile in healthy individuals and patients with gallstone disease from north and South India.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2016Article
- Cytotoxicity induced by nanobacteria and nanohydroxyapatites in human choriocarcinoma cells.Nanoscale research letters · 2014Article
- Calcifying nanoparticles: one face of distinct entities?Frontiers in microbiology · 2014Article
- Cytotoxicity and apoptosis induced by nanobacteria in human breast cancer cells.International journal of nanomedicine · 2014Article
- Bions: a family of biomimetic mineralo-organic complexes derived from biological fluids.PloS one · 2013Article
- New pathophysiological concepts underlying pathogenesis of pigment gallstones.Clinics and research in hepatology and gastroenterology · 2012Review
- The role of calcifying nanoparticles in biology and medicine.International journal of nanomedicine · 2012Review
- Evaluation of the interaction between calcifying nanoparticles and human dental pulp cells: a preliminary investigation.International journal of nanomedicine · 2010Article
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- Characterization of biofilm formed by human-derived nanoparticles.Nanomedicine (London, England) · 2009Article
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- Systemic injection of planktonic forms of mammalian-derived nanoparticles alters arterial response to injury in rabbits.American journal of physiology. Heart and circulatory physiology · 2009Article
- Putative nanobacteria represent physiological remnants and culture by-products of normal calcium homeostasis.PloS one · 2009Article
- Purported nanobacteria in human blood as calcium carbonate nanoparticles.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Do blood-borne calcifying nanoparticles self-propagate?International journal of nanomedicine · 2008Article
- Human-derived nanoparticles and vascular response to injury in rabbit carotid arteries: proof of principle.International journal of nanomedicine · 2008Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Black pigment gallstones are often founded in gallbladder, but their pathogenesis is unclear. The present study was undertaken to study the role of nanobacteria in pigment gallstone formation in Japanese white rabbits. Nanobacteria were successfully cultured from 3 of 7 cholecystolithiasis patients gallbladder (without acute cholecystitis) bile samples and affirmed by Hoechst 33258 staining and specific immunostaining using monoclonal antibody. Nanobacteria were injected into rabbits' gallbladder. After 2 weeks follow-up, the incidence of black pigment gallstones in rabbits was significantly greater in nanobacteria-injected group (8/10) than that in DMEM-injected group (2/10) and that in hydroxyapatite-injected group (2/10). This study indicates that nanobacteria exists in gallbladder bile of cholelithiasis patients and causes the formation of black pigment gallstones in rabbits. For the first time, we successfully established an animal model of black pigment gallstones caused by nanobacteria. This will be helpful in further delineating the pathogenesis of black pigment gallstones.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.