ReviewDigestive diseases and sciences2006
Hepatic ischemia-reperfusion injury: roles of Ca2+ and other intracellular mediators of impaired bile flow and hepatocyte damage.
Review in Digestive diseases and sciences, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 52 citations in OpenAlex.
- Protective strategies and therapeutic interventions for ischemia-reperfusion injury: potential applications in normothermic machine perfusion.Annals of medicine and surgery (2012) · 2025Review
- Role of TRP Channels in Liver-Related Diseases.International journal of molecular sciences · 2023Review
- TRPM2-mediated CaCell communication and signaling : CCS · 2023Review
- How Machine Perfusion Ameliorates Hepatic Ischaemia Reperfusion Injury.International journal of molecular sciences · 2021Review
- Inhibition of Drp1 SUMOylation by ALR protects the liver from ischemia-reperfusion injury.Cell death and differentiation · 2021Article
- The effects of oxytocin on penile tissues in experimental priapism model in rats.International urology and nephrology · 2019Article
- Machine Perfusion at 20°C Prevents Ischemic Injury and Reduces Hypoxia-Inducible Factor-1α Expression During Rat Liver Preservation.Annals of transplantation · 2017Article
- Effect of HSP27 and Cofilin in the injury of hypoxia/reoxygenation on hepatocyte membrane F-actin microfilaments.Medicine · 2017Observational
- Hepatic artery bridging lessens temporary ischemic injury to bile canaliculi.World journal of gastroenterology · 2015Article
- The effects of remote ischemic preconditioning and N-acetylcysteine with remote ischemic preconditioning in rat hepatic ischemia reperfusion injury model.BioMed research international · 2014Article
- Oxygen-sensitive mitochondrial accumulation of cystathionine β-synthase mediated by Lon protease.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Identification of a Calcium Signalling Pathway of S-[6]-Gingerol in HuH-7 Cells.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Hepatic steatosis prevents heme oxygenase-1 induction by isoflurane in the rat liver.World journal of gastroenterology · 2011Article
- Article
- Intermittent ischaemia maintains function after ischaemia reperfusion in steatotic livers.HPB : the official journal of the International Hepato Pancreato Biliary Association · 2010Article
- Measuring Ca2+ influxes of TRPC1-dependent Ca2+ channels in HL-7702 cells with non-invasive micro-test technique.World journal of gastroenterology · 2009Article
- Use of dissecting sealer may affect the early outcome in patients submitted to hepatic resection.HPB : the official journal of the International Hepato Pancreato Biliary Association · 2008Article
- Ischemic preconditioning and intermittent ischemia preserve bile flow in a rat model of ischemia/reperfusion injury.Digestive diseases and sciences · 2007Article
- Ischemic preconditioning and intermittent ischemia preserve bile flow in a rat model of ischemia reperfusion injury.Digestive diseases and sciences · 2007Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Liver resection and liver transplantation have been successful in the treatment of liver tumors and end-stage liver disease. This success has led to an expansion in the pool of patients potentially treatable by liver surgery and, in the case of transplantation, to a shortage of liver donors. At present, there are significant numbers of potential candidates for liver resection and liver donation who have fatty livers, are aged, or have livers damaged by chemotherapy. All of these are at high risk for ischemic reperfusion (IR) injury. The aims of this review are to assess current knowledge of the clinical effectiveness of ischemic preconditioning and intermittent ischemia in reducing IR damage in liver surgery; to evaluate the use of bile flow as a sensitive indicator of IR liver damage; and to analyze the molecular mechanisms, especially intracellular Ca2+, involved in IR injury and ischemic preconditioning. It is concluded that bile flow is a sensitive indicator of IR injury. Together with reactive oxygen species (ROS) and other extracellular and intracellular signaling molecules, intracellular Ca2+ in hepatocytes plays a key role in the normal regulation of bile flow and in IR-induced injury and cell death. Ischemic preconditioning is an effective strategy to reduce IR injury but there is considerable scope for improvement, especially in patients with fatty and aged livers. The development of effective new strategies to reduce IR injury will depend on improved understanding of the molecular mechanisms involved, especially by gaining a better perspective of the relative importance of the various intrahepatocyte signaling pathways involved.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.