Trial reportEuropean spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society2007
Randomised placebo-controlled trial on the effectiveness of nasal salmon calcitonin in the treatment of lumbar spinal stenosis.
Trial report in European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 5 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Effects of calcitonin on lumbar spinal stenosis.Archives of orthopaedic and trauma surgery · 2024Pooled it
- Non-operative treatment for lumbar spinal stenosis with neurogenic claudication: an updated systematic review.BMJ open · 2022Pooled it
- What interventions improve walking ability in neurogenic claudication with lumbar spinal stenosis? A systematic review.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2014Pooled it
- Nonoperative treatment for lumbar spinal stenosis with neurogenic claudication.The Cochrane database of systematic reviews · 2013Pooled it
- Quantitative radiologic criteria for the diagnosis of lumbar spinal stenosis: a systematic literature review.BMC musculoskeletal disorders · 2011Pooled it
- Nonsurgical interventions for lumbar spinal stenosis with neurogenic claudication: A systematic review and network meta-analysis.Integrative medicine research · 2026Article
- Validity of outcome measures used in randomized clinical trials and observational studies in degenerative lumbar spinal stenosis.Scientific reports · 2023Article
- To Assess Whether Lee's Grading System for Central Lumbar Spinal Stenosis Can Be Used as a Decision-Making Tool for Surgical Treatment.Taehan Yongsang Uihakhoe chi · 2022Article
- Calcitonin: A useful old friend.Journal of musculoskeletal & neuronal interactions · 2020Review
- Neurogenic Claudication: a Review of Current Understanding and Treatment Options.Current pain and headache reports · 2019Review
- Surgical and nonsurgical treatments for lumbar spinal stenosis.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2016Review
- Effects of Nasal Calcitonin vs. Oral Gabapentin on Pain and Symptoms of Lumbar Spinal Stenosis: A Clinical Trial Study.Clinical medicine insights. Arthritis and musculoskeletal disorders · 2016Article
- The efficacy of intramuscular calcitonin injection in the management of lumbar spinal stenosis.Asian spine journal · 2015Article
- Effects of calcitonin on lumbar spinal stenosis: a systematic review and meta-analysis.International journal of clinical and experimental medicine · 2015Article
- Review
- Lumbar spinal stenosis.Best practice & research. Clinical rheumatology · 2010Review
- A survey of the "surgical and research" articles in the European Spine Journal, 2007.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2008Review
- A survey of the "medical" articles in the European Spine Journal, 2007.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2008Review
- Investigating non-operative treatment options for lumbar spinal stenosis.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2007Article
- [Calcitonin as an analgesic agent: review of mechanisms of action and clinical applications].Brazilian journal of anesthesiology (Elsevier)Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This is a double blind randomised controlled trial to assess the effectiveness of nasal salmon calcitonin in the treatment of lumbar spinal stenosis. The trial compared the outcome of salmon calcitonin nasal spray to placebo nasal spray in patients with MRI confirmed lumbar spinal stenosis. Lumbar spinal stenosis is one of the commonest conditions encountered by spine surgeons. It more frequently affects elderly patients and lumbar decompression has been used to treat the condition with variable success. Non operative measures have been investigated, but their success ranges from 15% to 43% in patients followed up for 1-5 years (Simotas in Clin Orthop 1(384):153-161, 2001). Salmon calcitonin injections have been investigated in previous trials and may have a treatment effect. Nasal salmon calcitonin has become available and if effective would have advantages over injections. Forty patients with symptoms of neurogenic claudication and MRI proven lumbar spinal stenosis were randomly assigned either nasal salmon calcitonin or placebo nasal spray to use for 4 weeks. This was followed by a 'washout' period of 6 weeks, and subsequent treatment with 6 weeks of nasal salmon calcitonin. Standard spine outcome measures including Oswestry disability index (ODI), low back outcome score, visual analogue score and shuttle walking test were administered at baseline, 4, 10 and 16 weeks. Twenty patients received nasal salmon calcitonin and twenty patients received placebo nasal spray. At 4 weeks post treatment there was no statistically significant difference in the outcome measures between the two groups. The change in ODI was a mean 1.3 points for the calcitonin group and 0.6 points for the placebo group (P = 0.51), the mean change in visual analogue score for leg pain was 10 mm in the calcitonin group and 0 mm in the placebo group (P = 0.51). There was no significant difference in walking distance between the two groups, with a mean improvement in walking distance of 21 m in the calcitonin group and 8 m in the placebo group (P = 0.78). At the end of the trial the ODI had improved by a mean of 3.7 points in the calcitonin group and 3.8 points in the placebo group (P = 0.44). This randomised placebo controlled trial has not shown any treatment effect in patients with lumbar spinal stenosis treated with nasal salmon calcitonin.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.