ArticleWorld journal of surgery2006
Phyllodes tumor of the breast: the challenge persists.
Article in World journal of surgery, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.
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Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it, 98 citations in OpenAlex.
- Width of margins in phyllodes tumors of the breast: the controversy drags on?-a systematic review and meta-analysis.Breast cancer research and treatment · 2021Pooled it
- Adjuvant radiotherapy and chemotherapy for patients with breast phyllodes tumors: a systematic review and meta-analysis.BMC cancer · 2019Pooled it
- Circulating Tumor DNA (ctDNA) is Reliably Detected in Patients with Metastatic Malignant Phyllodes Tumors, a Feasibility Study.Annals of surgical oncology · 2025Article
- Clinicopathological characteristics and outcomes of phyllodes tumors in a tertiary care center: a retrospective study.Gland surgery · 2025Article
- Contemporary management of phyllodes tumours of the breast: recommendations from the UK Association of Breast Surgery.The British journal of surgery · 2025Article
- Malignant Mesenchymal Tumors of the Breast: Current Challenges and New Perspectives on Primary Sarcomas and Malignant Phyllodes Tumors.Life (Basel, Switzerland) · 2025Review
- Borderline Phyllodes Breast Tumors: A Comprehensive Review of Recurrence, Histopathological Characteristics, and Treatment Modalities.Current oncology (Toronto, Ont.) · 2025Review
- Exploring the clinical and histopathological characteristics on breast phyllodes tumors predictors and prognosis in a real world.Frontiers in oncology · 2025Article
- Article
- Recurrent giant phyllodes tumor of the breast: a case report.AME case reports · 2024Article
- Management of Benign Phyllodes Tumors: A Dutch Population-Based Retrospective Cohort Between 1989 and 2022.Annals of surgical oncology · 2023Article
- Prognostic factors of breast phyllodes tumors.Histology and histopathology · 2023Review
- Transformation of a Benign-Appearing Fibroepithelial Lesion to a Giant Malignant Phyllodes Tumor of the Breast.Cureus · 2022Article
- Local recurrence for phyllodes tumours of the breast: Systematic review and meta-analysis.Oncology letters · 2022Article
- Under- and Normal-Weight Patients Are More Susceptible to Recurrence of Phyllodes Tumor.The breast journal · 2022Article
- Contemporary Multi-Institutional Cohort of 550 Cases of Phyllodes Tumors (2007-2017) Demonstrates a Need for More Individualized Margin Guidelines.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2021Article
- Germline Genetic Mutations in a Multi-center Contemporary Cohort of 550 Phyllodes Tumors: An Opportunity for Expanded Multi-gene Panel Testing.Annals of surgical oncology · 2020Article
- Phyllodes Tumors of the Breast: A Literature Review.Cureus · 2020Review
- Radiopathological characteristics and outcomes of phyllodes tumor of the breast in Malaysian women.Medicine · 2018Article
- Prognostic factors in breast phyllodes tumors: a nomogram based on a retrospective cohort study of 404 patients.Cancer medicine · 2018Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionPhyllodes tumors of the breast are uncommon, and it is difficult to predict biologic behavior based on clinicopathologic features. Despite the wealth of data on the factors to predict recurrence, little is known about the impact of treatment refinements. This study seeks to define changes in patient characteristics, histopathologic parameters, and outcome between the two periods before and after the care of patients with breast diseases was centralized to a breast specialty.
methodsThe records of 182 patients with phyllodes tumors managed surgically were reviewed. Patients treated from 1985 to 1996 (n=81) were compared with those seen from 1997 to 2004 (n=101).
resultsThe analysis of the two treatment periods revealed that there was a decrease in tumor size at diagnosis, from 7.7 cm during the earlier period to 4.6 cm during the recent period (P=0.003). The patients undergoing breast-conserving surgery were significantly increased during the recent period. In contrast, pathologic features and local recurrence rates remained unchanged during the study period. Multivariate analysis revealed that positive surgical margin was the only independent predictor of recurrence, with an increased hazard of 8.0. Overall, upgrading to the next grade was observed in 16% of recurrences.
conclusionsBreast-conserving surgery with clear margins is the current treatment of choice for phyllodes tumors, but this strategy does not further reduce local recurrence effectively. Optimal management continues to be a challenge.
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