SynthesisJournal of human genetics2006
An association between asthma and TNF-308G/A polymorphism: meta-analysis.
Synthesis in Journal of human genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 4 syntheses or guidelines pooled it, 69 citations in OpenAlex.
- Receptor-interacting protein kinase 1 (RIPK1) as a therapeutic target.Nature reviews. Drug discovery · 2020Pooled it
- Association between tumor necrosis factor-α rs1800629 polymorphism and risk of asthma: a meta-analysis.PloS one · 2014Pooled it
- A meta-analysis on the association between three promoter variants of TNF-α and Crohn's disease.Molecular biology reports · 2012Pooled it
- The -308 G/A polymorphism in TNF-α gene is associated with asthma risk: an update by meta-analysis.Journal of clinical immunology · 2011Pooled it
- Establishment of a diagnostic model based on immune-related genes in children with asthma.Heliyon · 2024Article
- The Association of HHV-6 and theViruses · 2023Article
- Association of TNF-α (-308G/A) Gene Polymorphism with Changes in Circulating TNF-α Levels in Response to CPAP Treatment in Adults with Coronary Artery Disease and Obstructive Sleep Apnea.Journal of clinical medicine · 2023Article
- Peroxisome proliferator-activated receptor gamma gene variants modify human airway and systemic responses to indoor dibutyl phthalate exposure.Respiratory research · 2022Article
- Association analysis of genetic variants in the ghrelin and tumor necrosis factor α genes and the risk for non-Hodgkin's lymphoma in Kuwaitis.Cancer biomarkers : section A of Disease markers · 2021Article
- Review
- GSTP1 and TNF Gene variants and associations between air pollution and incident childhood asthma: the traffic, asthma and genetics (TAG) study.Environmental health perspectives · 2014Article
- Cytokine gene polymorphism and asthma susceptibility, progress and control level.Molecular biology reports · 2012Article
- Cosmopolitan and ethnic-specific replication of genetic risk factors for asthma in 2 Latino populations.The Journal of allergy and clinical immunology · 2011Article
- Labile anger during interferon alfa treatment is associated with a polymorphism in tumor necrosis factor alpha.Clinical neuropharmacology · 2010Article
- Strain-dependent activation of NF-kappaB in the airway epithelium and its role in allergic airway inflammation.American journal of physiology. Lung cellular and molecular physiology · 2010Article
- Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tumor necrosis factor (TNF) is a potent inflammatory cytokine that contributes to airway inflammation in asthma. Previous studies have reported that a G-to-A transition at position -308 (-308G/A, also referred to as TNF-alpha-308*1 and 308*2 respectively), is associated with asthma, but other studies have shown conflicting results. To investigate a possible association between the TNF-308G/A polymorphism and asthma, we performed transmission disequilibrium tests and a case-control study (family samples: 495 members in 165 Japanese trio families with one asthmatic child and both parents; case-control samples: 461 Japanese asthmatic children and 465 healthy controls). To increase the sample size and power, we performed a meta-analysis of all available relevant studies, including 2,477 asthmatics and 3,217 controls. We did not find a significant association between the TNF-308G/A polymorphism and childhood atopic asthma in two independent Japanese populations (P>0.05); however, meta-analysis revealed that the TNF-308G/A polymorphism was statistically significantly associated with asthma. The combined odds ratio with a fixed effects model and with a random effects for TNF-308A was 1.46 (95% confidence interval [CI], 1.27-1.68, P=0.0000001) and 1.46 (95% CI, 1.20-1.77, P=0.00014) respectively. Our data further support the importance of the TNF region in the development of asthma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.