ArticleProceedings of the National Academy of Sciences of the United States of America2006
Cellular asymmetry and individuality in directional sensing.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed.
- Computational modelling of cell motility modes emerging from cell-matrix adhesion dynamics.PLoS computational biology · 2022Article
- Maximization of information transmission influences selection of native phosphorelay architectures.PeerJ · 2021Article
- Cell-to-cell variation sets a tissue-rheology-dependent bound on collective gradient sensing.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- A critical-like collective state leads to long-range cell communication in Dictyostelium discoideum aggregation.PLoS biology · 2017Article
- Modeling Contact Inhibition of Locomotion of Colliding Cells Migrating on Micropatterned Substrates.PLoS computational biology · 2016Article
- Endothelial cells decode VEGF-mediated Ca2+ signaling patterns to produce distinct functional responses.Science signaling · 2016Article
- Regulation of Spatiotemporal Patterns by Biological Variability: General Principles and Applications to Dictyostelium discoideum.PLoS computational biology · 2015Review
- Cell memory and adaptation in chemotaxis.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Memory improves precision of cell sensing in fluctuating environments.Scientific reports · 2014Article
- Excitable signal transduction induces both spontaneous and directional cell asymmetries in the phosphatidylinositol lipid signaling system for eukaryotic chemotaxis.Biophysical journal · 2014Article
- Rho GTPases orient directional sensing in chemotaxis.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- High fidelity information processing in folic acid chemotaxis of Dictyostelium amoebae.Journal of the Royal Society, Interface · 2013Article
- Predictability of spatio-temporal patterns in a lattice of coupled FitzHugh-Nagumo oscillators.Journal of the Royal Society, Interface · 2013Article
- Migration of cells in a social context.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Interaction of motility, directional sensing, and polarity modules recreates the behaviors of chemotaxing cells.PLoS computational biology · 2013Article
- Modeling and measuring signal relay in noisy directed migration of cell groups.PLoS computational biology · 2013Article
- Diverse sensitivity thresholds in dynamic signaling responses by social amoebae.Science signaling · 2012Article
- Article
- 'Dicty dynamics': Dictyostelium motility as persistent random motion.Physical biology · 2011Article
- Chemotactic cell trapping in controlled alternating gradient fields.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
It is generally assumed that single cells in an isogenic population, when exposed to identical environments, exhibit the same behavior. However, it is becoming increasingly clear that, even in a genetically identical population, cellular behavior can vary significantly among cells. Here we explore this variability in the gradient-sensing response of Dictyostelium cells when exposed to repeated spatiotemporal pulses of chemoattractant. Our experiments show the response of a single cell to be highly reproducible from pulse to pulse. In contrast, a large variability in the response direction and magnitude is observed from cell to cell, even when different cells are exposed to the same pulse. First, these results indicate that the gradient-sensing network has inherent asymmetries that can significantly impact the ability of cells to faithfully sense the direction of extracellular signals (cellular asymmetry). Second, we find that the magnitude of this asymmetry varies greatly among cells. Some cells are able to accurately follow the direction of an extracellular stimulus, whereas, in other cells, the intracellular asymmetry dominates, resulting in a polarization axis that is independent of the direction of the extracellular cue (cellular individuality). We integrate these experimental findings into a model that treats the effective signal a cell detects as the product of the extracellular signal and the asymmetric intracellular signal. With this model we successfully predict the population response. This cellular individuality and asymmetry might fundamentally limit the fidelity of signal detection; in contrast, however, it might be beneficial by diversifying phenotypes in isogenic populations.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.