ArticleProceedings of the National Academy of Sciences of the United States of America2006
N-Myc and the cyclin-dependent kinase inhibitors p18Ink4c and p27Kip1 coordinately regulate cerebellar development.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 64 citations in OpenAlex.
- MYCN as an oncogene in pediatric brain tumors.Frontiers in oncology · 2025Review
- MYCN in human development and diseases.Frontiers in oncology · 2024Review
- MicroRNA-101a-3p mimic ameliorates spinal cord ischemia/reperfusion injury.Neural regeneration research · 2022Article
- Sonic Hedgehog Signaling in Cerebellar Development and Cancer.Frontiers in cell and developmental biology · 2022Review
- MYC in Brain Development and Cancer.International journal of molecular sciences · 2020Review
- Myc-Miz1 signaling promotes self-renewal of leukemia stem cells by repressing Cebpα and Cebpδ.Blood · 2020Article
- Preterm birth disrupts cerebellar development by affecting granule cell proliferation program and Bergmann glia.Experimental neurology · 2018Article
- Regulation ofMolecular cancer research : MCR · 2017Article
- cMyc Regulates the Size of the Premigratory Neural Crest Stem Cell Pool.Cell reports · 2016Article
- Article
- Role of the miR-17∼92 cluster family in cerebellar and medulloblastoma development.Biology open · 2014Article
- MYC proteins promote neuronal differentiation by controlling the mode of progenitor cell division.EMBO reports · 2014Article
- Role of MYC in Medulloblastoma.Cold Spring Harbor perspectives in medicine · 2013Review
- The deubiquitylase USP37 links REST to the control of p27 stability and cell proliferation.Oncogene · 2013Article
- N-Myc and L-Myc are essential for hair cell formation but not maintenance.Brain research · 2012Article
- Myc proteins in brain tumor development and maintenance.Upsala journal of medical sciences · 2012Article
- Constitutive gray hair in mice induced by melanocyte-specific deletion of c-Myc.Pigment cell & melanoma research · 2012Article
- A mouse model of the most aggressive subgroup of human medulloblastoma.Cancer cell · 2012Article
- N-Myc and GCN5 regulate significantly overlapping transcriptional programs in neural stem cells.PloS one · 2012Article
- Development and cancer of the cerebellum.Trends in neurosciences · 2011Review
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 2 countries.
Funding
Abstract
Conditional N-Myc deletion limits the proliferation of granule neuron progenitors (GNPs), perturbs foliation, and leads to reduced cerebellar mass. We show that c-Myc mRNA levels increase in N-Myc-null GNPs and that simultaneous deletion of both c- and N-Myc exacerbates defective cerebellar development. Moreover, N-Myc loss has been shown to trigger the precocious expression of two cyclin-dependent kinase inhibitors, Kip1 and Ink4c, in the cerebellar primordium. We now further demonstrate that the engineered disruption of the Kip1 and Ink4c genes in N-Myc-null cerebella partially rescues GNP cell proliferation and cerebellar foliation. These results provide definitive genetic evidence that expression of N-Myc and concomitant down-regulation of Ink4c and Kip1 contribute to the proper development of the cerebellum.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.