ArticleProceedings of the National Academy of Sciences of the United States of America2006
The role of the proline-rich domain of Ssdp1 in the modular architecture of the vertebrate head organizer.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 40 citations in OpenAlex.
- Single-stranded DNA-binding proteins are essential components of the architectural LDB1 protein complex.Molecular cell · 2025Article
- Planarian LDB and SSDP proteins scaffold transcriptional complexes for regeneration and patterning.Developmental biology · 2024Article
- Xenopus Ssbp2 is required for embryonic pronephros morphogenesis and terminal differentiation.Scientific reports · 2023Article
- The ortholog of human ssDNA-binding protein SSBP3 influences neurodevelopment and autism-like behaviors in Drosophila melanogaster.PLoS biology · 2023Article
- Crystal structure of human LDB1 in complex with SSBP2.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- The Lhx1-Ldb1 complex interacts with Furry to regulate microRNA expression during pronephric kidney development.Scientific reports · 2018Article
- Possible Role of Single Stranded DNA Binding Protein 3 on Skin Hydration by Regulating Epidermal Differentiation.Annals of dermatology · 2018Article
- Single-stranded DNA binding protein Ssbp3 induces differentiation of mouse embryonic stem cells into trophoblast-like cells.Stem cell research & therapy · 2016Article
- Single-stranded DNA binding proteins are required for LIM complexes to induce transcriptionally active chromatin and specify spinal neuronal identities.Development (Cambridge, England) · 2016Article
- SSBP3 Interacts With Islet-1 and Ldb1 to Impact Pancreatic β-Cell Target Genes.Molecular endocrinology (Baltimore, Md.) · 2015Article
- Systems genetic analysis of hippocampal neuroanatomy and spatial learning in mice.Genes, brain, and behavior · 2015Article
- Lhx1 functions together with Otx2, Foxa2, and Ldb1 to govern anterior mesendoderm, node, and midline development.Genes & development · 2015Article
- Requirement for ssbp2 in hematopoietic stem cell maintenance and stress response.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Developmental mechanisms directing early anterior forebrain specification in vertebrates.Cellular and molecular life sciences : CMLS · 2013Review
- Multivalent binding of formin-binding protein 21 (FBP21)-tandem-WW domains fosters protein recognition in the pre-spliceosome.The Journal of biological chemistry · 2011Article
- SSDP cofactors regulate neural patterning and differentiation of specific axonal projections.Developmental biology · 2011Article
- Regulation of C. elegans presynaptic differentiation and neurite branching via a novel signaling pathway initiated by SAM-10.Development (Cambridge, England) · 2011Article
- HNCA-TOCSY-CANH experiments with alternate (13)C- (12)C labeling: a set of 3D experiment with unique supra-sequential information for mainchain resonance assignment.Journal of biomolecular NMR · 2011Article
- Nitrogen-detected CAN and CON experiments as alternative experiments for main chain NMR resonance assignments.Journal of biomolecular NMR · 2010Article
- A mouse chromosome 4 balancer ENU-mutagenesis screen isolates eleven lethal lines.BMC genetics · 2009Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Lim1, Ssdp1, and Ldb1 proteins are components of the Ldb1-associated transcriptional complex, which is important in the head-organizing activity during early mouse development. Depletion of each individual protein alone causes a headless phenotype. To explore in more detail the modular architecture of the complex, we have generated two different gene-trapped mouse lines that express truncated forms of Ssdp1. Embryos derived from the gene-trapped line that encodes a truncated Ssdp1 lacking the proline-rich sequence exhibit a lethal abnormal head-development phenotype, resembling mouse embryos deficient for Lim1, Ssdp1, or Otx2 genes. Embryos derived from the second gene-trapped line, in which most of the proline-rich domain of Ssdp1 is retained, did not show abnormalities in head development. Our data demonstrate that components of the Ldb1-dependent module can be subdivided further into discrete functional domains and that the proline-rich stretch of Ssdp1 is critical for embryonic head development. Furthermore, phylogenetic comparisons revealed that in Caenorhabditis elegans, a similar proline-rich sequence is absent in Ssdp but present in Ldb1. We conclude that although the overall architecture of the Ldb1-dependent module has been preserved, the genetic specification of its individual components has diversified during evolution, without compromising the function of the module.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.