ArticlePLoS computational biology2006
Circadian rhythmicity by autocatalysis.
Article in PLoS computational biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Reconstitution of circadian clock in synthetic cells reveals principles of timekeeping.Nature communications · 2025Article
- When lowering temperature, the in vivo circadian clock in cyanobacteria follows and surpasses the in vitro protein clock trough the Hopf bifurcation.Scientific reports · 2025Article
- Computational modelling unravels the precise clockwork of cyanobacteria.Interface focus · 2018Review
- A thermodynamically consistent model of the post-translational Kai circadian clock.PLoS computational biology · 2017Article
- Systems Biology-Derived Discoveries of Intrinsic Clocks.Frontiers in neurology · 2017Review
- Kernel Architecture of the Genetic Circuitry of the Arabidopsis Circadian System.PLoS computational biology · 2016Article
- Toward Multiscale Models of Cyanobacterial Growth: A Modular Approach.Frontiers in bioengineering and biotechnology · 2016Review
- KaiC intersubunit communication facilitates robustness of circadian rhythms in cyanobacteria.Nature communications · 2013Article
- Structural and dynamic aspects of protein clocks: how can they be so slow and stable?Cellular and molecular life sciences : CMLS · 2012Review
- Generic temperature compensation of biological clocks by autonomous regulation of catalyst concentration.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Quantifying the rhythm of KaiB-C interaction for in vitro cyanobacterial circadian clock.PloS one · 2012Article
- The cyanobacterial circadian system: from biophysics to bioevolution.Annual review of biophysics · 2011Review
- The itty-bitty time machine genetics of the cyanobacterial circadian clock.Advances in genetics · 2011Review
- Robust circadian clocks from coupled protein-modification and transcription-translation cycles.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- A sequestration feedback determines dynamics and temperature entrainment of the KaiABC circadian clock.Molecular systems biology · 2010Article
- Synchronization of circadian oscillation of phosphorylation level of KaiC in vitro.Biophysical journal · 2010Article
- The molecular clockwork of a protein-based circadian oscillator.FEBS letters · 2009Review
- Circadian KaiC phosphorylation: a multi-layer network.PLoS computational biology · 2009Article
- 'Glocal' robustness analysis and model discrimination for circadian oscillators.PLoS computational biology · 2009Article
- Effect of continuous light on diurnal rhythms in Cyanothece sp. ATCC 51142.BMC genomics · 2009Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The temperature compensated in vitro oscillation of cyanobacterial KaiC phosphorylation, the first example of a thermodynamically closed system showing circadian rhythmicity, only involves the three Kai proteins (KaiA, KaiB, and KaiC) and ATP. In this paper, we describe a model in which the KaiA- and KaiB-assisted autocatalytic phosphorylation and dephosphorylation of KaiC are the source for circadian rhythmicity. This model, based upon autocatalysis instead of transcription-translation negative feedback, shows temperature-compensated circadian limit-cycle oscillations with KaiC phosphorylation profiles and has period lengths and rate constant values that are consistent with experimental observations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.