ArticleNeurochemical research1991
Release of acetylcholine and GABA, and activity of their synthesizing enzymes in the rat pontine reticular formation.
Article in Neurochemical research, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 9 citations in OpenAlex.
- Sleep and Anesthesia Interactions: A Pharmacological Appraisal.Current anesthesiology reports · 2013Article
- Pontine reticular formation (PnO) administration of hypocretin-1 increases PnO GABA levels and wakefulness.Sleep · 2008Review
- Cholinergic neurons in the pedunculopontine tegmental nucleus are involved in the mediation of prepulse inhibition of the acoustic startle response in the rat.Experimental brain research · 1993Article
- Levels, uptake, and release of glycine and glutamate in the rat pontine reticular formation.Neurochemical research · 1992Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to obtain neurochemical information on the possible role of acetylcholine (ACh) and gamma-aminobutyric acid (GABA) as neurotransmitters in the pontine reticular formation (PRF). We studied the uptake of labeled choline and GABA, as well as the release of this amino acid and of ACh, in PRF slices of the rat. In addition, choline acetyltransferase, acetylcholinesterase and glutamate decarboxylase activities were assayed in PRF homogenates. The uptake of GABA was strictly Na(+)-dependent, whereas choline uptake was only partially Na(+)-dependent. The release of both ACh and GABA was stimulated by K(+)-depolarization, but only the former was Ca(2+)-dependent. Choline acetyltransferase activity in the PRF was 74% of that in the striatum, whereas acetylcholinesterase activity was considerably lower. Glutamate decarboxylase activity in the PRF was about half that observed in the striatum. These findings support the possibility that both ACh and GABA may act as neurotransmitters in the rat PRF.
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Registered trials
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