Trial reportJournal of psychiatry & neuroscience : JPN2006
Increased olfactory sensitivity in euthymic patients with bipolar disorder with event-related episodes compared with patients with bipolar disorder without such episodes.
Trial report in Journal of psychiatry & neuroscience : JPN, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- Olfactory Dysfunction in Mental Illness.Current allergy and asthma reports · 2023Review
- Variations in olfactory function among bipolar disorder patients with different episodes and subtypes.Frontiers in psychiatry · 2023Article
- Association Between Anxious Symptom Severity and Olfactory Impairment in Young Adults with Generalized Anxiety Disorder: A Case-Control Study.Neuropsychiatric disease and treatment · 2021Article
- Depression, Olfaction, and Quality of Life: A Mutual Relationship.Brain sciences · 2018Review
- Olfactory Functioning in First-Episode Psychosis.Schizophrenia bulletin · 2018Article
- TLX: A master regulator for neural stem cell maintenance and neurogenesis.Biochimica et biophysica acta · 2015Review
- Sadness might isolate you in a non-smelling world: olfactory perception and depression.Frontiers in psychology · 2014Review
- Olfactory acuity is associated with mood and function in a pilot study of stable bipolar disorder patients.Bipolar disorders · 2012Article
- Olfactory identification and preference in bipolar disorder and schizophrenia.European archives of psychiatry and clinical neuroscience · 2011Article
- Neuronal generator patterns of olfactory event-related brain potentials in schizophrenia.Psychophysiology · 2010Article
- Hyperactivity, startle reactivity and cell-proliferation deficits are resistant to chronic lithium treatment in adult Nr2e1(frc/frc) mice.Genes, brain, and behavior · 2010Article
- An fMRI study of working memory in persons with bipolar disorder or at genetic risk for bipolar disorder.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2010Article
- Diagnostic validity of sensory over-responsivity: a review of the literature and case reports.Journal of autism and developmental disorders · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveSome patients with bipolar disorder experience mood episodes following emotional life events, whereas others do not. There is evidence that orbitofrontal hypoactivity may be related to this, because the orbitofrontal cortex is involved in the regulation of emotional and behavioural responses to external events. The close anatomical and functional connection between the orbitofrontal cortex and olfactory processing suggests that patients with bipolar disorder and heightened emotional reactivity may exhibit altered olfactory function compared with patients with bipolar disorder who do not exhibit this sensitivity.
methodsIn this pilot study, olfactory function was assessed in patients with bipolar disorder and a history of event-triggered episodes (n = 7) and in patients with bipolar disorder without such a history (n = 9) at the Department of Psychiatry and the Taste and Smell Clinic of the University of Dresden, Germany. Each patient's bipolar disorder was in remission at study entry, and they were on monotherapy with mood stabilizers. Assessment included olfactory event-related potentials (ERP) and psychophysical tests for odour threshold, odour identification and olfactory quality discrimination.
resultsOdour thresholds were lower in patients with bipolar disorder and event-triggered episodes compared with the other patient group. In addition, patients with event-triggered episodes exhibited shorter N1 peak latencies of the olfactory ERP.
conclusionsOur findings indicate disinhibition of orbitofrontal areas involved in the processing of emotional events in a subset of patients with bipolar illness.
Indexed as
Identifiers
16862244PMC1488901What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.