ArticleOncogene2007
Relationship between E1A binding to cellular proteins, c-myc activation and S-phase induction.
Article in Oncogene, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
- The adenoviral E1A N-terminal domain represses MYC transcription in human cancer cells by targeting both p300 and TRRAP and inhibiting MYC promoter acetylation of H3K18 and H4K16.Genes & cancer · 2016Article
- The Cellular Protein Complex Associated with a Transforming Region of E1A Contains c-MYC.Journal of virology · 2016Article
- Predictive genetic markers of coagulation, inflammation and apoptosis in Perthes disease—Serbian experience.European journal of pediatrics · 2015Article
- E1a promotes c-Myc-dependent replicative stress: implications in glioblastoma radiosensitization.Cell cycle (Georgetown, Tex.) · 2014Article
- Adenovirus E1A oncogene induces rereplication of cellular DNA and alters DNA replication dynamics.Journal of virology · 2013Article
- Protein kinase A regulates MYC protein through transcriptional and post-translational mechanisms in a catalytic subunit isoform-specific manner.The Journal of biological chemistry · 2013Article
- Down-regulation of the transcriptional mediator subunit Med1 contributes to the loss of expression of metastasis-associated dapk1 in human cancers and cancer cells.International journal of cancer · 2009Article
- Increased OXPHOS activity precedes rise in glycolytic rate in H-RasV12/E1A transformed fibroblasts that develop a Warburg phenotype.Molecular cancer · 2009Article
- c-Myc-induced aberrant DNA synthesis and activation of DNA damage response in p300 knockdown cells.The Journal of biological chemistry · 2009Article
- Adenovirus transforming protein E1A induces c-Myc in quiescent cells by a novel mechanism.Journal of virology · 2009Article
- Enhanced estrogen-induced proliferation in obese rat endometrium.American journal of obstetrics and gynecology · 2009Article
- p300 provides a corepressor function by cooperating with YY1 and HDAC3 to repress c-Myc.Oncogene · 2008Article
- Evaluation of E1A double mutant oncolytic adenovectors in anti-glioma gene therapy.Journal of medical virology · 2008Article
- Simian virus 40 large T overcomes p300 repression of c-Myc.Virology · 2008Article
- Adenovirus E1A targets p400 to induce the cellular oncoprotein Myc.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
We recently showed that p300/CREB-binding protein (CBP) plays an important role in maintaining cells in G0/G1 phase by keeping c-myc in a repressed state. Consistent with this, adenovirus E1A oncoprotein induces c-myc in a p300-dependent manner, and the c-myc induction is linked to S-phase induction. The induction of S phase by E1A is dependent on its binding to and inactivating several host proteins including p300/CBP. To determine whether there is a correlation between the host proteins binding to the N-terminal region of E1A, activation of c-myc and induction of S phase, we assayed the c-myc and S-phase induction in quiescent human cells by infecting them with Ad N-terminal E1A mutants with mutations that specifically affect binding to different chromatin-associated proteins including pRb, p300, p400 and p300/CBP-associated factor (PCAF). We show that the mutants that failed to bind to p300 or pRb were severely defective for c-myc and S-phase induction. The induction of c-myc and S phase was only moderately affected when E1A failed to bind to p400. Furthermore, analysis of the E1A mutants that fail to bind to p300, and both p300 and PCAF suggests that PCAF may also play a role in c-myc repression, and that the two chromatin-associated proteins may repress c-myc independently. In summary, these results suggest that c-myc deregulation by E1A through its interaction with these chromatin-associated proteins is an important step in the E1A-mediated cell cycle deregulation and possibly in cell transformation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.