ArticleInfection and immunity2006
Role of transcription factor T-bet expression by CD4+ cells in gastritis due to Helicobacter pylori in mice.
Article in Infection and immunity, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 41 citations in OpenAlex.
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- CD103 Promotes the Pro-inflammatory Response of Gastric Resident CD4Frontiers in cellular and infection microbiology · 2020Article
- Regulation of Gastric Lgr5+ve Cell Homeostasis by Bone Morphogenetic Protein (BMP) Signaling and Inflammatory Stimuli.Cellular and molecular gastroenterology and hepatology · 2018Article
- Regulation of Gastric Metaplasia, Dysplasia, and Neoplasia by Bone Morphogenetic Protein Signaling.Cellular and molecular gastroenterology and hepatology · 2017Review
- Interferon-γ-producing B cells induce the formation of gastric lymphoid follicles after Helicobacter suis infection.Mucosal immunology · 2015Article
- Helicobacter pylori and T Helper Cells: Mechanisms of Immune Escape and Tolerance.Journal of immunology research · 2015Review
- Anti-inflammatory activity of bone morphogenetic protein signaling pathways in stomachs of mice.Gastroenterology · 2014Article
- Article
- Impairment of ghrelin synthesis in Helicobacter pylori-colonized stomach: new clues for the pathogenesis of H. pylori-related gastric inflammation.World journal of gastroenterology · 2014Review
- Complex T cell interactions contribute to Helicobacter pylori gastritis in mice.Infection and immunity · 2013Article
- The Helicobacter pylori autotransporter ImaA (HP0289) modulates the immune response and contributes to host colonization.Infection and immunity · 2012Article
- Innate-like CD4 T cells selected by thymocytes suppress adaptive immune responses against bacterial infections.Open journal of immunology · 2012Article
- IFN-γ inhibits gastric carcinogenesis by inducing epithelial cell autophagy and T-cell apoptosis.Cancer research · 2011Article
- Ulcerative typhlocolitis associated with Helicobacter mastomyrinus in telomerase-deficient mice.Veterinary pathology · 2011Article
- Immunization with dendritic cells pulsed ex vivo with recombinant chlamydial protease-like activity factor induces protective immunity against genital chlamydiamuridarum challenge.Frontiers in immunology · 2011Article
- Helicobacter pylori and gastric cancer: factors that modulate disease risk.Clinical microbiology reviews · 2010Review
- Role of innate immunity in Helicobacter pylori-induced gastric malignancy.Physiological reviews · 2010Review
- Partial protection against Helicobacter pylori in the absence of mast cells in mice.Infection and immunity · 2009Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Gastritis due to Helicobacter pylori is induced by a Th1-mediated response that is CD4 cell and gamma interferon (IFN-gamma) dependent. T-bet is a transcription factor that directs differentiation of and IFN-gamma secretion by CD4+ Th1 T cells. The goal of this study was to use two mouse models to elucidate the role of T-bet in gastritis due to H. pylori. C57BL/6J mice, congenic T-bet knockout (KO) mutants, or congenic SCID (severe, combined immunodeficient) mutants were given live H. pylori by oral inoculation. SCID mice were given CD4+ splenocytes from C57BL/6J or T-bet KO mice by intraperitoneal injection. Twelve or 24 weeks after bacterial inoculation, C57BL/6J mice developed moderate gastritis but T-bet KO mice and SCID mice did not. In contrast, SCID recipients of either C57BL/6J T cells or T-bet KO T cells developed gastritis 4 or 8 weeks after adoptive transfer. In recipients of C57BL/6J CD4+ cells but not recipients of T-bet KO cells, gastritis was associated with a delayed-type hypersensitivity response to H. pylori antigen and elevated gastric and serum IFN-gamma, interleukin 6, and tumor necrosis factor alpha. In spite of the absence of IFN-gamma expression, indicating failure of Th1 differentiation, CD4+ T cells from T-bet KO mice induce gastritis in H. pylori-infected recipient SCID mice. This indicates that Th1-independent mechanisms can cause gastric inflammation and disease due to H. pylori.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.