ArticleInfection and immunity2006
Diversity of the T-cell response to pulmonary Cryptococcus neoformans infection.
Article in Infection and immunity, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 24 citations in OpenAlex.
- ReportedFEMS microbes · 2026Article
- Pulmonary granuloma formation during latentmBio · 2025Article
- State of the Field: Cytotoxic Immune Cell Responses inJournal of fungi (Basel, Switzerland) · 2024Review
- They shall not grow mold: Soldiers of innate and adaptive immunity to fungi.Seminars in immunology · 2023Review
- Glucuronoxylomannan in the Cryptococcus species capsule as a target for Chimeric Antigen Receptor T-cell therapy.Cytotherapy · 2021Article
- Disseminated Cryptococcosis with Rapidly Growing Lung Nodules in an End-stage Renal Disease Patient.Internal medicine (Tokyo, Japan) · 2017Article
- Adaptive Immunity toJournal of fungi (Basel, Switzerland) · 2017Article
- Gender-specific contributing risk factors and outcome of female cryptococcal meningoencephalitis patients.BMC infectious diseases · 2016Article
- The Cnes2 locus on mouse chromosome 17 regulates host defense against cryptococcal infection through pleiotropic effects on host immunity.Infection and immunity · 2015Article
- Immunity to Cryptococcus neoformans and C. gattii during cryptococcosis.Fungal genetics and biology : FG & B · 2015Review
- The intracellular life of Cryptococcus neoformans.Annual review of pathology · 2014Review
- Early induction of CCL7 downstream of TLR9 signaling promotes the development of robust immunity to cryptococcal infection.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- The magnitude of CD4(+) T-cell activation rather than TCR diversity determines the outcome of Leishmania infection in mice.Parasite immunology · 2011Article
- Robust Th1 and Th17 immunity supports pulmonary clearance but cannot prevent systemic dissemination of highly virulent Cryptococcus neoformans H99.The American journal of pathology · 2009Article
- Cryptococcal urease promotes the accumulation of immature dendritic cells and a non-protective T2 immune response within the lung.The American journal of pathology · 2009Article
- Loss of allergen 1 confers a hypervirulent phenotype that resembles mucoid switch variants of Cryptococcus neoformans.Infection and immunity · 2009Article
- PI3K signaling of autophagy is required for starvation tolerance and virulenceof Cryptococcus neoformans.The Journal of clinical investigation · 2008Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Cell-mediated immunity plays an important role in immunity to the pathogenic fungus Cryptococcus neoformans. However, the antigen specificity of the T-cell response to C. neoformans remains largely unknown. In this study, we used two approaches to determine the antigen specificity of the T-cell response to C. neoformans. We report here that a diverse T-cell receptor (TCR) Vbeta repertoire was maintained throughout the primary response to pulmonary C. neoformans infection in immunocompetent mice. CD4+ T-cell deficiency resulted in relative expansion of all CD8+ T-cell subsets. During a secondary immune response, preferential usage of a TCR Vbeta subset in CD4+ T cells occurred in single individuals, but the preferences were "private" and not shared between individuals. Both CD4+ and CD8+ T cells from the secondary lymphoid tissues of immunized mice proliferated in response to a variety of C. neoformans antigens, including heat-killed whole C. neoformans, culture filtrate antigen, C. neoformans lysate, and purified cryptococcal mannoprotein. CD4+ and CD8+ T cells from the secondary lymphoid tissues of mice undergoing a primary response to C. neoformans proliferated in response to C. neoformans lysate. In response to stimulation with C. neoformans lysate, lung CD4+ and CD8+ T cells produced the effector cytokines tumor necrosis factor alpha and gamma interferon. These results demonstrate that a diverse T-cell response is generated in response to pulmonary C. neoformans infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.