ArticleInfection and immunity2006
Signal transduction, gene transcription, and cytokine production triggered in macrophages by exposure to trypanosome DNA.
Article in Infection and immunity, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 43 citations in OpenAlex.
- Plasma cytokines quantification amongMalawi medical journal : the journal of Medical Association of Malawi · 2021Article
- Salivarian Trypanosomosis: A Review of Parasites Involved, Their Global Distribution and Their Interaction With the Innate and Adaptive Mammalian Host Immune System.Frontiers in immunology · 2018Review
- Inflammatory and Pro-resolving Lipids in Trypanosomatid Infections: A Key to Understanding Parasite Control.Frontiers in microbiology · 2018Review
- Host cell signalling and leishmania mechanisms of evasion.Journal of tropical medicine · 2012Article
- Urinary tract infections caused by staphylococcus aureus DNA in comparison to the candida albicans DNA.North American journal of medical sciences · 2011Article
- The biocompatibility of sulfobetaine engineered polymethylmethacrylate by surface entrapment technique.Journal of materials science. Materials in medicine · 2010Article
- Immunobiology of African trypanosomes: need of alternative interventions.Journal of biomedicine & biotechnology · 2010Article
- Processing and presentation of variant surface glycoprotein molecules to T cells in African trypanosomiasis.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- TecoflexTM functionalization by curdlan and its effect on protein adsorption and bacterial and tissue cell adhesion.Journal of materials science. Materials in medicine · 2009Article
- Functional aspects of Toll-like receptor/MyD88 signalling during protozoan infection: focus on Toxoplasma gondii.Clinical and experimental immunology · 2009Review
- Type I IFNs play a role in early resistance, but subsequent susceptibility, to the African trypanosomes.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- CpG oligodeoxynucleotide treatment enhances innate resistance and acquired immunity to African trypanosomes.Infection and immunity · 2007Article
- Protozoan encounters with Toll-like receptor signalling pathways: implications for host parasitism.Nature reviews. Immunology · 2006Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Activation of a type I cytokine response is important for early resistance to infection with Trypanosoma brucei rhodesiense, the extracellular protozoan parasite that causes African sleeping sickness. The work presented here demonstrates that trypanosome DNA activates macrophages to produce factors that may contribute to this response. Initial results demonstrated that T. brucei rhodesiense DNA was present in the plasma of C57BL/6 and C57BL/6-scid mice following infection. Subsequently, the effect of trypanosome DNA on macrophages was investigated; parasite DNA was found to be less stimulatory than Escherichia coli DNA but more stimulatory than murine DNA, as predicted by the CG dinucleotide content. Trypanosome DNA stimulated the induction of a signal transduction cascade associated with Toll-like receptor signaling in RAW 264.7 macrophage cells. The signaling cascade led to expression of mRNAs, including interleukin-12 (IL-12) p40, IL-6, IL-10, cyclooxygenase-2, and beta interferon. The treatment of RAW 264.7 cells and bone marrow-derived macrophages with trypanosome DNA induced the production of NO, prostaglandin E2, and the cytokines IL-6, IL-10, IL-12, and tumor necrosis factor alpha. In all cases, DNase I treatment of T. brucei rhodesisense DNA abolished the activation. These results suggest that T. brucei rhodesiense DNA serves as a ligand for innate immune cells and may play an important contributory role in early stimulation of the host immune response during trypanosomiasis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.