Trial reportInfection and immunity2006
Filaria-induced monocyte dysfunction and its reversal following treatment.
Trial report in Infection and immunity, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 61 citations in OpenAlex.
- The human immunome in the post-schistosomiasis mass drug administration era.PLoS neglected tropical diseases · 2026Review
- Reversal of filarial serpin Wb123-urokinase plasminogen activator receptor mediated alternative macrophage activation by monoclonal antibody.PLoS neglected tropical diseases · 2025Article
- Immunoendocrine network under conditions of diabetes-filariasis co-morbidity DMLF6.Scientific reports · 2025Article
- Article
- Individuals co-exposed to sand fly saliva and filarial parasites exhibit altered monocyte function.PLoS neglected tropical diseases · 2021Article
- Extracellular vesicles released from the filarial parasite Brugia malayi downregulate the host mTOR pathway.PLoS neglected tropical diseases · 2021Article
- Ivermectin inhibits extracellular vesicle secretion from parasitic nematodes.Journal of extracellular vesicles · 2020Article
- CpG enhances the immunogenicity of heterologous DNA-prime/protein-boost vaccination with the heavy chain myosin of Brugia malayi in BALB/c mice.Parasitology research · 2019Article
- Transcriptome-wide analysis of filarial extract-primed human monocytes reveal changes in LPS-induced PTX3 expression levels.Scientific reports · 2019Article
- Association of aThe American journal of tropical medicine and hygiene · 2019Article
- Similarities and differences between helminth parasites and cancer cell lines in shaping human monocytes: Insights into parallel mechanisms of immune evasion.PLoS neglected tropical diseases · 2018Article
- Human innate lymphoid cells (ILCs) in filarial infections.Parasite immunology · 2018Review
- Helminth parasites and immune regulation.F1000Research · 2018Review
- Regulatory monocytes in helminth infections: insights from the modulation during human hookworm infection.BMC infectious diseases · 2017Article
- Improving T Cell Expansion with a Soft Touch.Nano letters · 2017Article
- Differential immunomodulation in human monocytes versus macrophages by filarial cystatin.PloS one · 2017Article
- Mycobacteria induce TPL-2 mediated IL-10 in IL-4-generated alternatively activated macrophages.PloS one · 2017Article
- Microfilariae of Brugia malayi Inhibit the mTOR Pathway and Induce Autophagy in Human Dendritic Cells.Infection and immunity · 2016Article
- Host parasite communications-Messages from helminths for the immune system: Parasite communication and cell-cell interactions.Molecular and biochemical parasitology · 2016Review
- Regulatory T-cell neutralization in mice during filariasis helps in parasite clearance by enhancing T helper type 17-mediated pro-inflammatory response.Immunology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
Abstract
Monocyte dysfunction in filarial infection has been proposed as one mechanism underlying the diminished antigen-specific T-cell response seen in patent lymphatic filariasis. Cytokine/chemokine production and gene expression in monocytes from filaria-infected patients and uninfected healthy donors were assessed unstimulated and in response to stimulation with Staphylococcus aureus Cowan I bacteria plus gamma interferon both before and 8 months following treatment. Monocytes from filaria-infected individuals were studded with intracellular microfilarial antigens. Furthermore, monocytes from these individuals were less capable of producing interleukin-8 (IL-8), Exodus II, MIP-1alpha, MIP-1beta, and IL-1alpha and preferentially expressed genes involved in apoptosis and adhesion compared with monocytes from uninfected donors. Eight months following treatment with a single dose of ivermectin-albendazole, some of these defects were reversed, with monocyte production of IL-8, IL-1alpha, MIP-1alpha, and IL-10 being comparable to that seen in the uninfected controls. In addition, a marked increase in mRNA expression of genes associated with protein metabolism, particularly heat shock proteins, was seen compared with pretreatment expression. These data suggest that the function and gene expression of monocytes in filaria-infected patients are altered but that this dysfunction is partially reversible following antifilarial treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.