ArticlePlant physiology2007
Characterization of a novel plant promoter specifically induced by heavy metal and identification of the promoter regions conferring heavy metal responsiveness.
Article in Plant physiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 61 citations in OpenAlex.
- Molecular Mechanisms of Cadmium Stress Resistance in Vegetable Crops.International journal of molecular sciences · 2025Review
- Promoters, KeyInternational journal of molecular sciences · 2024Review
- The Contribution ofFoods (Basel, Switzerland) · 2024Article
- The TabHLH35-TaWAK20-TaSPL5 pathway positively regulates Cd stress in wheat.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Article
- microRNA408 and its encoded peptide regulate sulfur assimilation and arsenic stress response in Arabidopsis.Plant physiology · 2023Article
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- Plant Promoters and Terminators for High-Precision Bioengineering.Biodesign research · 2023Review
- Identification of transcription factor binding sites on promoter ofPhysiology and molecular biology of plants : an international journal of functional plant biology · 2019Article
- The role of receptor-like protein kinases (RLKs) in abiotic stress response in plants.Plant cell reports · 2017Review
- Article
- Bean metal-responsive element-binding transcription factor confers cadmium resistance in tobacco.Plant physiology · 2015Article
- The new insights into cadmium sensing.Frontiers in plant science · 2014Review
- Article
- A common response to common danger? Comparison of animal and plant signaling pathways involved in cadmium sensing.Journal of cell communication and signaling · 2012Article
- MicroRNAs as regulators in plant metal toxicity response.Frontiers in plant science · 2012Article
- Microarray-based analysis of cadmium-responsive microRNAs in rice (Oryza sativa).Journal of experimental botany · 2011Article
- Article
- Orthologs of the class A4 heat shock transcription factor HsfA4a confer cadmium tolerance in wheat and rice.The Plant cell · 2009Article
- Tissue-specific expression of the PNZIP promoter is mediated by combinatorial interaction of different cis-elements and a novel transcriptional factor.Nucleic acids research · 2009Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The bean (Phaseolus vulgaris) stress-related gene number 2 (PvSR2) gene responds to heavy metals but not to other forms of environmental stresses. To elucidate its heavy metal-regulatory mechanism at the transcriptional level, we isolated and characterized the promoter region (-1623/+48) of PvSR2. Deletions from the 5' end revealed that a sequence between -222 and -147 relative to the transcriptional start site was sufficient for heavy metal-specific induction of the promoter region of PvSR2. Detailed analysis of this 76-bp fragment indicated that heavy metal-responsive elements were localized in two regions (-222/-188 and -187/-147), each of which could separately confer heavy metal-responsive expression on the beta-glucuronidase gene in the context of a minimal cauliflower mosaic virus 35S promoter. Region I (-222/-188) contains a motif (metal-regulatory element-like sequence) similar to the consensus metal-regulatory element of the animal metallothionein gene, and mutation of this motif eliminated the heavy metal-inducible function of region I. Region II (-187/-147) had no similarity to previously identified cis-acting elements involved in heavy metal induction, suggesting the presence of a novel heavy metal-responsive element. Transformed tobacco (Nicotiana tabacum) seedlings expressing beta-glucuronidase under control of the PvSR2 promoter region (-687/+48) showed heavy metal-specific responsive activity that depended on the type and concentration of the heavy metal and the type of organ. These findings further our understanding of the regulation of PvSR2 expression and provide a new heavy-metal-inducible promoter system in transgenic plants.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.