ArticleArchives of disease in childhood2006
The national neonatal screening programme for congenital toxoplasmosis in Denmark: results from the initial four years, 1999-2002.
Article in Archives of disease in childhood, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
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Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 90 citations in OpenAlex.
- Adverse Event Profile of Pyrimethamine-Based Therapy in Toxoplasmosis: A Systematic Review.Drugs in R&D · 2017Pooled it
- Prenatal education for congenital toxoplasmosis.The Cochrane database of systematic reviews · 2015Pooled it
- Congenital toxoplasmosis and prenatal care state programs.BMC infectious diseases · 2014Trial
- Using dried blood spots to estimate Toxoplasma gondii seroprevalence in pregnant women in Catalonia, Spain, and to serologically diagnose congenital toxoplasmosis.PLoS neglected tropical diseases · 2026Article
- Anti-Pathogens (Basel, Switzerland) · 2023Review
- Congenital toxoplasmosis among hospitalized infants in Poland in the years 2007-2021: study based on the national hospital registry.Scientific reports · 2023Article
- Risk factors for acute toxoplasmosis in the Netherlands.Epidemiology and infection · 2023Article
- Antenatal Screening for Toxoplasmosis and Rubella in Saudi Arabia: Assessing the Need for Screening.Journal of multidisciplinary healthcare · 2023Article
- Article
- Toxoplasmosis Infection in Newborn: A Systematic Review and Meta-analysis.Advanced biomedical research · 2022Review
- Seroprevalence ofThe Pan African medical journal · 2022Article
- The disease burden of ocular toxoplasmosis in Denmark in 2019: Estimates based on laboratory testing of ocular samples and on publicly available register data.Parasite epidemiology and control · 2021Article
- Congenital toxoplasmosis in humans: an update of worldwide rate of congenital infections.Parasitology · 2021Review
- Molecular and serological study on congenital toxoplasmosis in newborn of Shiraz, Southern Iran.Environmental science and pollution research international · 2021Article
- Prevention and mitigation of congenital toxoplasmosis. Economic costs and benefits in diverse settings.Food and waterborne parasitology · 2019Review
- Basic heel prick test: inclusion of screening, diagnosis and criteria for early confirmation of congenital infection by Toxoplasma gondii.Revista do Instituto de Medicina Tropical de Sao Paulo · 2019Article
- Treatment of toxoplasmosis: Current options and future perspectives.Food and waterborne parasitology · 2019Review
- Article
- Observational study to assess pregnant women's knowledge and behaviour to prevent toxoplasmosis, listeriosis and cytomegalovirus.BMC pregnancy and childbirth · 2013Article
- "Blind periods" in screening for toxoplasmosis in pregnancy in Austria - a debate.BMC infectious diseases · 2012Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo describe the outcome of four years' nationwide neonatal screening for congenital toxoplasmosis in liveborn newborns.
methodsCongenital toxoplasmosis was diagnosed if specific Toxoplasma gondii IgM antibodies were detected in eluate from the PKU Guthrie filter paper card from a child. Infants diagnosed with congenital toxoplasmosis were examined for intracranial and retinal lesions and treated for three months with sulphadiazine, pyrimethamine, and folinic acid continuously.
resultsEluates from PKU-cards from 262 912 newborns were analysed. The birth prevalence of congenital toxoplasma infection was 2.1 per 10 000 liveborns. Congenital toxoplasmosis was suspected in 96 infants and confirmed in 55. Forty seven children were examined for intracranial and retinal lesions soon after birth; 12 had clinical signs at this first examination. Of these, 5 had intracranial calcifications, 2 had retinochoroidal lesions, 4 had intracranial calcifications and retinochoroidal lesions, and 1 had hydrocephalus, intracranial calcifications, and retinochoroidal lesions. Ninety four eyes were examined soon after birth; there were central retinochoroidal lesions in 9. Two children had macular lesion of both eyes, five had macular lesions of one eye. At 1 year of age, 10/68 eyes had central lesions, and at 3 years of age, 5/32 had central lesions. Thus new retinochoroidal lesions developed in three eyes in the observation period.
conclusionsNeonatal screening is feasible for diagnosing children with congenital toxoplasmosis at birth in low endemic areas. Retinochoroiditis with macular lesion was diagnosed in 9.6% of the eyes at birth and in 15.6% of the eyes examined at 3 years of age.
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