ArticleProceedings of the National Academy of Sciences of the United States of America2006
The Ets factor Spi-B is a direct critical target of the coactivator OBF-1.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 41 citations in OpenAlex.
- The Role of the Transcriptional Coactivator BOB.1/OBF.1 in Adaptive Immunity.Advances in experimental medicine and biology · 2024Review
- SpiB regulates the expression of B-cell-related genes and increases the longevity of memory B cells.Frontiers in immunology · 2023Article
- The transcriptional program during germinal center reaction - a close view at GC B cells, Tfh cells and Tfr cells.Frontiers in immunology · 2023Review
- Adrenergic signaling controls early transcriptional programs during CD8+ T cell responses to viral infection.PloS one · 2022Article
- Transcriptional regulation of memory B cell differentiation.Nature reviews. Immunology · 2021Review
- rs1944919 on chromosome 11q23.1 and its effector genes COLCA1/COLCA2 confer susceptibility to primary biliary cholangitis.Scientific reports · 2021Article
- Unique Immune Cell Coactivators Specify Locus Control Region Function and Cell Stage.Molecular cell · 2020Article
- The Transcriptional Regulation of Germinal Center Formation.Frontiers in immunology · 2018Review
- TNF-α augments RANKL-dependent intestinal M cell differentiation in enteroid cultures.American journal of physiology. Cell physiology · 2016Article
- Natalizumab-induced POU2AF1/Spi-B upregulation: A possible route for PML development.Neurology(R) neuroimmunology & neuroinflammation · 2016Article
- The generation of antibody-secreting plasma cells.Nature reviews. Immunology · 2015Review
- Limitation of immune tolerance-inducing thymic epithelial cell development by Spi-B-mediated negative feedback regulation.The Journal of experimental medicine · 2014Article
- Immunological Markers for PML Prediction in MS Patients Treated with Natalizumab.Frontiers in immunology · 2014Review
- Oct2 and Obf1 as Facilitators of B:T Cell Collaboration during a Humoral Immune Response.Frontiers in immunology · 2014Article
- Hematopoietic overexpression of FOG1 does not affect B-cells but reduces the number of circulating eosinophils.PloS one · 2014Article
- B and T cells collaborate in antiviral responses via IL-6, IL-21, and transcriptional activator and coactivator, Oct2 and OBF-1.The Journal of experimental medicine · 2012Article
- Genome-wide association study identifies TNFSF15 and POU2AF1 as susceptibility loci for primary biliary cirrhosis in the Japanese population.American journal of human genetics · 2012Article
- Analysis of select members of the E26 (ETS) transcription factors family in colorectal cancer.Virchows Archiv : an international journal of pathology · 2011Article
- Transcription factor Spi-B binds unique sequences present in the tandem repeat promoter/enhancer of JC virus and supports viral activity.The Journal of general virology · 2010Article
- Distinct regulatory mechanism of immunoglobulin gene transcription in epithelial cancer cells.Cellular & molecular immunology · 2010Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
OBF-1 (Bob.1, OCA-B) is a lymphoid-specific transcriptional coactivator that associates with the transcription factors Oct-1 or Oct-2 on the conserved octamer element present in the promoters of several ubiquitous and lymphoid-specific genes. OBF-1-deficient mice have B cell-intrinsic defects, lack germinal centers, and have severely impaired immune responses to T cell-dependent antigens. Crucial genes that are regulated by OBF-1 and that might explain the observed phenotype of OBF-1 deficiency have remained elusive to date. Here we have generated transgenic mice expressing OBF-1 specifically in T cells and examined these together with mice lacking OBF-1 to discover transcriptional targets of this coactivator. Using microarray analysis, we have identified the Ets transcription factor Spi-B as a direct target gene critically regulated by OBF-1 that can help explain the phenotype of OBF-1-deficient mice. Spi-B has been implicated in signaling pathways downstream of the B cell receptor and is essential for germinal center formation and maintenance. The present findings establish a hierarchy between these two factors and provide a molecular link between OBF-1 and B cell receptor signaling.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.