ArticleBiophysical journal2006
Perlwapin, an abalone nacre protein with three four-disulfide core (whey acidic protein) domains, inhibits the growth of calcium carbonate crystals.
Article in Biophysical journal, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
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- Core genes of biomineralization and cis-regulatory long non-coding RNA regulate shell growth in bivalves.Journal of advanced research · 2024Article
- Research progress on formation mechanism of pearl.Heliyon · 2024Article
- A Novel Kunitz-Type Serine Protease Inhibitor (HcKuSPI) is Involved in Antibacterial Defense in Innate Immunity and Participates in Shell Formation of Hyriopsis cumingii.Marine biotechnology (New York, N.Y.) · 2024Article
- Transcriptional regulation analysis reveals the complexity of metamorphosis in the Pacific oyster (Marine life science & technology · 2023Article
- On the wave of the crustin antimicrobial peptide family: From sequence diversity to function.Fish and shellfish immunology reports · 2022Review
- Organic Matrix and Secondary Metabolites in Nacre.Marine biotechnology (New York, N.Y.) · 2022Review
- Transcriptomic analysis of shell repair and biomineralization in the blue mussel, Mytilus edulis.BMC genomics · 2021Article
- Transcriptomic analysis of the poultry red mite, Dermanyssus gallinae, across all stages of the lifecycle.BMC genomics · 2021Article
- Transcriptome Expression of Biomineralization Genes in Littoraria flava Gastropod in Brazilian Rocky Shore Reveals Evidence of Local Adaptation.Genome biology and evolution · 2021Article
- Diversified Biomineralization Roles ofInternational journal of molecular sciences · 2021Article
- Transcriptome analysis of the uterus of hens laying eggs differing in cuticle deposition.BMC genomics · 2020Article
- Molecular and Functional Diversity of Crustin-Like Genes in the ShrimpMarine drugs · 2020Article
- Pearl Sac Gene Expression Profiles Associated With Pearl Attributes in the Silver-Lip Pearl Oyster,Frontiers in genetics · 2020Article
- In-depth proteomic analyses ofProteome science · 2018Article
- Identification and Differential Expression of Biomineralization Genes in the Mantle of Pearl Oyster Pinctada fucata.Marine biotechnology (New York, N.Y.) · 2017Article
- Transcriptome analysis of the freshwater pearl mussel (Cristaria plicata) mantle unravels genes involved in the formation of shell and pearl.Molecular genetics and genomics : MGG · 2017Article
- Insights from the Shell Proteome: Biomineralization to Adaptation.Molecular biology and evolution · 2017Article
- Deep conservation of bivalve nacre proteins highlighted by shell matrix proteomics of the Unionoida Elliptio complanata and Villosa lienosa.Journal of the Royal Society, Interface · 2017Article
- A proteinaceous organic matrix regulates carbonate mineral production in the marine teleost intestine.Scientific reports · 2016Article
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4 authors.
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Abstract
We have isolated a new protein from the nacreous layer of the shell of the sea snail Haliotis laevigata (abalone). Amino acid sequence analysis showed the protein to consist of 134 amino acids and to contain three sequence repeats of approximately 40 amino acids which were very similar to the well-known whey acidic protein domains of other proteins. The new protein was therefore named perlwapin. In addition to the major sequence, we identified several minor variants. Atomic force microscopy was used to explore the interaction of perlwapin with calcite crystals. Monomolecular layers of calcite crystals dissolve very slowly in deionized water and recrystallize in supersaturated calcium carbonate solution. When perlwapin was dissolved in the supersaturated calcium carbonate solution, growth of the crystal was inhibited immediately. Perlwapin molecules bound tightly to distinct step edges, preventing the crystal layers from growing. Using lower concentrations of perlwapin in a saturated calcium carbonate solution, we could distinguish native, active perlwapin molecules from denaturated ones. These observations showed that perlwapin can act as a growth inhibitor for calcium carbonate crystals in saturated calcium carbonate solution. The function of perlwapin in nacre growth may be to inhibit the growth of certain crystallographic planes in the mineral phase of the polymer/mineral composite nacre.
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