ArticleGenome biology2006
A method for high-throughput gene expression signature analysis.
Article in Genome biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 117 papers.
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Who cites it
117 citing papers in PubMed.
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- Building a credibility-based framework for target discovery: Perspectives from tRNA synthetase-linked metabolic diseases.Briefings in bioinformatics · 2026Article
- High-throughput profiling of chemical-induced gene expression across 93,644 perturbations.Nature methods · 2025Article
- A decision point between transdifferentiation and programmed cell death priming controls KRAS-dependent pancreatic cancer development.Nature communications · 2025Article
- Pulsatilla chinensis functions as a novel antihyperlipidemic agent by upregulating LDLR in an ERK-dependent manner.Chinese medicine · 2024Article
- DOSE-L1000: unveiling the intricate landscape of compound-induced transcriptional changes.Bioinformatics (Oxford, England) · 2023Article
- Overexpression of synaptic vesicle protein Rab GTPase 3C promotes vesicular exocytosis and drug resistance in colorectal cancer cells.Molecular oncology · 2023Article
- High-dimensional gene expression and morphology profiles of cells across 28,000 genetic and chemical perturbations.Nature methods · 2022Article
- Clonal barcoding with qPCR detection enables live cell functional analyses for cancer research.Nature communications · 2022Article
- Cell Painting predicts impact of lung cancer variants.Molecular biology of the cell · 2022Article
- Multiplex Glycan Bead Array (MGBA ) for High Throughput and High Content Analyses of Glycan-Binding Proteins Including Natural Anti-Glycan Antibodies.Methods in molecular biology (Clifton, N.J.) · 2022Article
- A human liver cell-based system modeling a clinical prognostic liver signature for therapeutic discovery.Nature communications · 2021Article
- Deep Large-Scale Multitask Learning Network for Gene Expression Inference.Journal of computational biology : a journal of computational molecular cell biology · 2021Article
- High-Throughput Strategies for the Discovery of Anticancer Drugs by Targeting Transcriptional Reprogramming.Frontiers in oncology · 2021Review
- A flexible, interpretable, and accurate approach for imputing the expression of unmeasured genes.Nucleic acids research · 2020Article
- signatureSearch: environment for gene expression signature searching and functional interpretation.Nucleic acids research · 2020Article
- A Gene Expression High-Throughput Screen (GE-HTS) for Coordinated Detection of Functionally Similar Effectors in Cancer.Cancers · 2020Review
- Gene-signature-derived ICScientific reports · 2020Article
- Uncovering the key dimensions of high-throughput biomolecular data using deep learning.Nucleic acids research · 2020Article
57 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genome-wide transcriptional profiling has shown that different biologic states (for instance, disease and response to pharmacologic manipulation) can be recognized by the expression pattern of relatively small numbers of genes. However, the lack of a practical and cost-effective technology for detection of these gene expression 'signatures' in large numbers of samples has severely limited their exploitation in important medical and pharmaceutical discovery applications. Here, we describe a solution based on the combination of ligation-mediated amplification with an optically addressed microsphere and flow cytometric detection system.
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