ArticleThe Review of scientific instruments2006
Thin-foil magnetic force system for high-numerical-aperture microscopy.
Article in The Review of scientific instruments, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed.
- Single-molecule magnetic tweezers to unravel protein folding dynamics under force.Biophysical reviews · 2025Review
- Unravelling DNA Organization with Single-Molecule Force Spectroscopy Using Magnetic Tweezers.Methods in molecular biology (Clifton, N.J.) · 2024Article
- A Critical Review on the Sensing, Control, and Manipulation of Single Molecules on Optofluidic Devices.Micromachines · 2022Review
- Recent Progress of Magnetically Actuated DNA Micro/Nanorobots.Cyborg and bionic systems (Washington, D.C.) · 2022Review
- Studying structure and functions of cell membranes by single molecule biophysical techniques.Biophysics reports · 2021Article
- Cancer cells display increased migration and deformability in pace with metastatic progression.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Article
- Ephemeral states in protein folding under force captured with a magnetic tweezers design.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Vinculin and metavinculin exhibit distinct effects on focal adhesion properties, cell migration, and mechanotransduction.PloS one · 2019Article
- Remodeling Tissue Interfaces and the Thermodynamics of Zipping during Dorsal Closure in Drosophila.Biophysical journal · 2015Article
- Micro-elastometry on whole blood clots using actuated surface-attached posts (ASAPs).Lab on a chip · 2015Article
- TGF-β regulates LARG and GEF-H1 during EMT to affect stiffening response to force and cell invasion.Molecular biology of the cell · 2014Article
- Vinculin phosphorylation differentially regulates mechanotransduction at cell-cell and cell-matrix adhesions.The Journal of cell biology · 2014Article
- Magnetic force micropiston: an integrated force/microfluidic device for the application of compressive forces in a confined environment.The Review of scientific instruments · 2014Article
- Nonlinear signatures of entangled polymer solutions in active microbead rheology.Journal of rheology · 2013Article
- Established and novel methods of interrogating two-dimensional cell migration.Integrative biology : quantitative biosciences from nano to macro · 2012Review
- The vinculin C-terminal hairpin mediates F-actin bundle formation, focal adhesion, and cell mechanical properties.The Journal of biological chemistry · 2011Article
- A microfabricated magnetic force transducer-microaspiration system for studying membrane mechanics.Physical biology · 2011Article
- Mechanical stiffness grades metastatic potential in patient tumor cells and in cancer cell lines.Cancer research · 2011Article
- Design and Modeling of a 3-D Magnetic Actuator for Magnetic Microbead Manipulation.IEEE/ASME transactions on mechatronics : a joint publication of the IEEE Industrial Electronics Society and the ASME Dynamic Systems and Control Division · 2011Article
- The Rho GEFs LARG and GEF-H1 regulate the mechanical response to force on integrins.Nature cell biology · 2011Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Forces play a key role in a wide range of biological phenomena from single-protein conformational dynamics to transcription and cell division, to name a few. The majority of existing microbiological force application methods can be divided into two categories: those that can apply relatively high forces through the use of a physical connection to a probe and those that apply smaller forces with a detached probe. Existing magnetic manipulators utilizing high fields and high field gradients have been able to reduce this gap in maximum applicable force, but the size of such devices has limited their use in applications where high force and high-numerical-aperture (NA) microscopy must be combined. We have developed a magnetic manipulation system that is capable of applying forces in excess of 700 pN on a 1 mum paramagnetic particle and 13 nN on a 4.5 mum paramagnetic particle, forces over the full 4pi sr, and a bandwidth in excess of 3 kHz while remaining compatible with a commercially available high-NA microscope objective. Our system design separates the pole tips from the flux coils so that the magnetic-field geometry at the sample is determined by removable thin-foil pole plates, allowing easy change from experiment to experiment. In addition, we have combined the magnetic manipulator with a feedback-enhanced, high-resolution (2.4 nm), high-bandwidth (10 kHz), long-range (100 mum xyz range) laser tracking system. We demonstrate the usefulness of this system in a study of the role of forces in higher-order chromosome structure and function.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.