ArticleThe EMBO journal2006
Complex interaction of Drosophila GRIP PDZ domains and Echinoid during muscle morphogenesis.
Article in The EMBO journal, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 30 citations in OpenAlex.
- Myotendinous Junction development and repair.Journal of orthopaedic translation · 2026Review
- The cell-adhesion molecule Echinoid promotes tissue survival and separately restricts tissue overgrowth.Development (Cambridge, England) · 2025Article
- Single-cell transcriptomics illuminates regulatory steps driving anterior-posterior patterning of Drosophila embryonic mesoderm.Cell reports · 2023Article
- Developmental origin of tendon diversity inFrontiers in physiology · 2023Review
- Review
- Hecate/Grip2a acts to reorganize the cytoskeleton in the symmetry-breaking event of embryonic axis induction.PLoS genetics · 2014Article
- Drosophila importin-7 functions upstream of the Elmo signaling module to mediate the formation and stability of muscle attachments.Journal of cell science · 2013Article
- Post-transcriptional regulation of myotube elongation and myogenesis by Hoi Polloi.Development (Cambridge, England) · 2013Article
- Cooperation of Syd-1 with Neurexin synchronizes pre- with postsynaptic assembly.Nature neuroscience · 2012Article
- The development of the myotendinous junction. A review.Muscles, ligaments and tendons journal · 2012Article
- Moleskin is essential for the formation of the myotendinous junction in Drosophila.Developmental biology · 2011Article
- Asymmetric distribution of Echinoid defines the epidermal leading edge during Drosophila dorsal closure.The Journal of cell biology · 2011Article
- Born to run: creating the muscle fiber.Current opinion in cell biology · 2010Review
- Connecting muscles to tendons: tendons and musculoskeletal development in flies and vertebrates.Development (Cambridge, England) · 2010Review
- Cytoskeletal remodeling during myotube assembly and guidance: coordinating the actin and microtubule networks.Communicative & integrative biology · 2009Article
- RacGAP50C directs perinuclear gamma-tubulin localization to organize the uniform microtubule array required for Drosophila myotube extension.Development (Cambridge, England) · 2009Article
- Gephyrin interacts with the glutamate receptor interacting protein 1 isoforms at GABAergic synapses.Journal of neurochemistry · 2008Article
- Morphogenesis of the somatic musculature in Drosophila melanogaster.Wiley interdisciplinary reviews. Developmental biologyReview
- "Importin" signaling roles for import proteins: the function of Drosophila importin-7 (DIM-7) in muscle-tendon signaling.Cell adhesion & migrationArticle
Corrections and comments
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Authors and funding
8 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glutamate receptor interacting protein (GRIP) homologues, initially characterized in synaptic glutamate receptor trafficking, consist of seven PDZ domains (PDZDs), whose conserved arrangement is of unknown significance. The Drosophila GRIP homologue (DGrip) is needed for proper guidance of embryonic somatic muscles towards epidermal attachment sites, with both excessive and reduced DGrip activity producing specific phenotypes in separate muscle groups. These phenotypes were utilized to analyze the molecular architecture underlying DGrip signaling function in vivo. Surprisingly, removing PDZDs 1-3 (DGripDelta1-3) or deleting ligand binding in PDZDs 1 or 2 convert DGrip to excessive in vivo activity mediated by ligand binding to PDZD 7. Yeast two-hybrid screening identifies the cell adhesion protein Echinoid's (Ed) type II PDZD-interaction motif as binding PDZDs 1, 2 and 7 of DGrip. ed loss-of-function alleles exhibit muscle defects, enhance defects caused by reduced DGrip activity and suppress the dominant DGripDelta1-3 effect during embryonic muscle formation. We propose that Ed and DGrip form a signaling complex, where competition between N-terminal and the C-terminal PDZDs of DGrip for Ed binding controls signaling function.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.