ArticleThe EMBO journal2006
Xenopus laevis POU91 protein, an Oct3/4 homologue, regulates competence transitions from mesoderm to neural cell fates.
Article in The EMBO journal, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25 citing papers in PubMed, 56 citations in OpenAlex.
- Constructing the pharyngula: Connecting the primary axial tissues of the head with the posterior axial tissues of the tail.Cells & development · 2023Review
- Nodal and <i>churchill1</i> position the expression of a notch ligand during <i>Xenopus</i> germ layer segregation.Life science alliance · 2022Article
- The functional diversity of the POUV-class proteins across vertebrates.Open biology · 2022Review
- Neural is Fundamental: Neural Stemness as the Ground State of Cell Tumorigenicity and Differentiation Potential.Stem cell reviews and reports · 2022Review
- Modeling Bainbridge-Ropers Syndrome inFrontiers in physiology · 2020Article
- New roles for Wnt and BMP signaling in neural anteroposterior patterning.EMBO reports · 2019Article
- A novel role for Ascl1 in the regulation of mesendoderm formation via HDAC-dependent antagonism of VegT.Development (Cambridge, England) · 2016Article
- Endogenous gradients of resting potential instructively pattern embryonic neural tissue via Notch signaling and regulation of proliferation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Neural transcription factors: from embryos to neural stem cells.Molecules and cells · 2014Review
- Spalt-like 4 promotes posterior neural fates via repression of pou5f3 family members in Xenopus.Development (Cambridge, England) · 2014Article
- A conserved Oct4/POUV-dependent network links adhesion and migration to progenitor maintenance.Current biology : CB · 2013Article
- Oct4 is required ~E7.5 for proliferation in the primitive streak.PLoS genetics · 2013Article
- Zebrafish churchill regulates developmental gene expression and cell migration.Developmental dynamics : an official publication of the American Association of Anatomists · 2013Article
- Regulation of germ layer formation by pluripotency factors during embryogenesis.Cell & bioscience · 2013Article
- On becoming neural: what the embryo can tell us about differentiating neural stem cells.American journal of stem cells · 2013Article
- Suv4-20h histone methyltransferases promote neuroectodermal differentiation by silencing the pluripotency-associated Oct-25 gene.PLoS genetics · 2013Article
- Identification of a pou2 ortholog in Chinese sturgeon, Acipenser sinensis and its expression patterns in tissues, immature individuals and during embryogenesis.Fish physiology and biochemistry · 2012Article
- Focal adhesion kinase protein regulates Wnt3a gene expression to control cell fate specification in the developing neural plate.Molecular biology of the cell · 2011Article
- Interaction of Sox1, Sox2, Sox3 and Oct4 during primary neurogenesis.Developmental biology · 2011Article
- Geminin cooperates with Polycomb to restrain multi-lineage commitment in the early embryo.Development (Cambridge, England) · 2011Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cellular competence is defined as a cell's ability to respond to signaling cues as a function of time. In Xenopus laevis, cellular responsiveness to fibroblast growth factor (FGF) changes during development. At blastula stages, FGF induces mesoderm, but at gastrula stages FGF regulates neuroectoderm formation. A Xenopus Oct3/4 homologue gene, XLPOU91, regulates mesoderm to neuroectoderm transitions. Ectopic XLPOU91 expression in Xenopus embryos inhibits FGF induction of Brachyury (Xbra), eliminating mesoderm, whereas neural induction is unaffected. XLPOU91 knockdown induces high levels of Xbra expression, with blastopore closure being delayed to later neurula stages. In morphant ectoderm explants, mesoderm responsiveness to FGF is extended from blastula to gastrula stages. The initial expression of mesoderm and endoderm markers is normal, but neural induction is abolished. Churchill (chch) and Sip1, two genes regulating neural competence, are not expressed in XLPOU91 morphant embryos. Ectopic Sip1 or chch expression rescues the morphant phenotype. Thus, XLPOU91 epistatically lies upstream of chch/Sip1 gene expression, regulating the competence transition that is critical for neural induction. In the absence of XLPOU91 activity, the cues driving proper embryonic cell fates are lost.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.