ArticleAmerican journal of respiratory cell and molecular biology2006
Thrombin and TNF-alpha/IL-1beta synergistically induce fibroblast-mediated collagen gel degradation.
Article in American journal of respiratory cell and molecular biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 46 citations in OpenAlex.
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- Straight to the heart: Pleiotropic antiarrhythmic actions of oral anticoagulants.Pharmacological research · 2019Review
- Role of corneal collagen fibrils in corneal disorders and related pathological conditions.International journal of ophthalmology · 2017Review
- Intervention of transforming pulmonary fibrosis with NF-κB p65 antisense oligonucleotide.International journal of clinical and experimental medicine · 2014Article
- Hemostasis and alterations of the central nervous system.Seminars in thrombosis and hemostasis · 2013Review
- Effect of budesonide on fibroblast-mediated collagen gel contraction and degradation.Journal of inflammation research · 2013Article
- Pin1 protein regulates Smad protein signaling and pulmonary fibrosis.The Journal of biological chemistry · 2012Article
- Regulated expressions of MMP-2, -9 by diterpenoids from Euphorbia formosana Hayata.Molecules (Basel, Switzerland) · 2012Article
- Coagulation and autoimmunity in scleroderma interstitial lung disease.Seminars in arthritis and rheumatism · 2011Review
- The P2Y(2) nucleotide receptor mediates tissue factor expression in human coronary artery endothelial cells.The Journal of biological chemistry · 2011Article
- The effects of thrombin and cytokines upon the biomechanics and remodeling of isolated amnion membrane, in vitro.Placenta · 2011Article
- TFPI-2 silencing increases tumour progression and promotes metalloproteinase 1 and 3 induction through tumour-stromal cell interactions.Journal of cellular and molecular medicine · 2011Article
- Article
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Authors and funding
7 authors at 2 institutions in 3 countries.
Funding
Abstract
Degradation of preexisting and newly synthesized extracellular matrix is thought to play an important role in tissue remodeling. The current study evaluated whether thrombin and TNF-alpha/IL-1beta could collaboratively induce collagen degradation by human fetal lung fibroblasts (HFL-1) and adult bronchial fibroblasts cultured in three-dimensional collagen gels. TNF-alpha/IL-1beta alone induced production of matrix metalloproteinases (MMPs)-1, -3, and -9, which were released in latent form. With the addition of thrombin, the latent MMPs were converted into active forms and this resulted in collagen gel degradation. Part of the activation of MMPs by thrombin resulted from direct activation of MMP-1, MMP-2, MMP-3, and MMP-9 in the absence of cells. In addition, tissue inhibitor of metalloproteinase-1 production was inhibited by the combination of thrombin and TNF-alpha/IL-1beta. These results suggest that thrombin and TNF-alpha/IL-1beta synergize to induce degradation of three-dimensional collagen gels through increasing the production and activation of MMPs, and that this effect is mediated through both direct activation of MMPs by thrombin and indirectly by thrombin activation of fibroblasts. Through such mechanisms, thrombin could contribute to many chronic lung disorders characterized by tissue remodeling.
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