ReviewThe Journal of physiology2006
The complexity of the mammalian transcriptome.
Review in The Journal of physiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed.
- Trial
- MicroRNA and Proteomic Landscape of Brain Development.Neurochemical research · 2026Article
- Article
- Estimating transcriptome complexities across eukaryotes.BMC genomics · 2023Article
- How Placenta Promotes the Successful Reproduction in High-Altitude Populations: A Transcriptome Comparison between Adaptation and Acclimatization.Molecular biology and evolution · 2022Article
- The roles of glycolysis in osteosarcoma.Frontiers in pharmacology · 2022Review
- A comprehensive rat transcriptome built from large scale RNA-seq-based annotation.Nucleic acids research · 2020Article
- Methodologies for Transcript Profiling Using Long-Read Technologies.Frontiers in genetics · 2020Review
- Deep sequencing of small non-coding RNA highlights brain-specific expression patterns and RNA cleavage.RNA biology · 2019Article
- MiR-34 and MiR-200: Regulator of Cell Fate Plasticity and Neural Development.Neuromolecular medicine · 2019Review
- Isolation, Culture and Functional Characterization of Glia and Endothelial Cells From Adult Pig Brain.Frontiers in cellular neuroscience · 2019Article
- Transcriptional Complexity and Distinct Expression Patterns ofG3 (Bethesda, Md.) · 2017Article
- Review
- Characterization of GPR101 transcript structure and expression patterns.Journal of molecular endocrinology · 2016Article
- Transcriptome analysis revealed chimeric RNAs, single nucleotide polymorphisms and allele-specific expression in porcine prenatal skeletal muscle.Scientific reports · 2016Article
- The Antisense Transcriptome and the Human Brain.Journal of molecular neuroscience : MN · 2016Review
- Identification and annotation of conserved promoters and macrophage-expressed genes in the pig genome.BMC genomics · 2015Article
- Insights into the Transcriptional Architecture of Behavioral Plasticity in the Honey Bee Apis mellifera.Scientific reports · 2015Article
- Complex expression of the UL136 gene of human cytomegalovirus results in multiple protein isoforms with unique roles in replication.Journal of virology · 2014Article
- Reovirus-mediated induction of ADAR1 (p150) minimally alters RNA editing patterns in discrete brain regions.Molecular and cellular neurosciences · 2014Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A comprehensive understanding of protein and regulatory networks is strictly dependent on the complete description of the transcriptome of cells. After the determination of the genome sequence of several mammalian species, gene identification is based on in silico predictions followed by evidence of transcription. Conservative estimates suggest that there are about 20,000 protein-encoding genes in the mammalian genome. In the last few years the combination of full-length cDNA cloning, cap-analysis gene expression (CAGE) tag sequencing and tiling arrays experiments have unveiled unexpected additional complexities in the transcriptome. Here we describe the current view of the mammalian transcriptome focusing on transcripts diversity, the growing non-coding RNA world, the organization of transcriptional units in the genome and promoter structures. In-depth analysis of the brain transcriptome has been challenging due to the cellular complexity of this organ. Here we present a computational analysis of CAGE data from different regions of the central nervous system, suggesting distinctive mechanisms of brain-specific transcription.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.