ArticlePLoS biology2006
High-resolution mutation mapping reveals parallel experimental evolution in yeast.
Article in PLoS biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed.
- Species-wide survey of the expressivity and complexity spectrum of traits in yeast.PLoS genetics · 2024Article
- Editorial: Integrating multi-scale approaches for predicting microbiome ecology and evolution.Frontiers in microbiology · 2022Article
- Experimental Evolution in Plant-Microbe Systems: A Tool for Deciphering the Functioning and Evolution of Plant-Associated Microbial Communities.Frontiers in microbiology · 2021Review
- Evolutionary Repair Experiments as a Window to the Molecular Diversity of Life.Current biology : CB · 2020Review
- Evolution of a novel chimeric maltotriose transporter in Saccharomyces eubayanus from parent proteins unable to perform this function.PLoS genetics · 2019Article
- Article
- Quantitative Trait Nucleotides Impacting the Technological Performances of IndustrialFrontiers in genetics · 2019Article
- Evolutionary dynamics in the fungal polarization network, a mechanistic perspective.Biophysical reviews · 2017Review
- Article
- Engineering tolerance to industrially relevant stress factors in yeast cell factories.FEMS yeast research · 2017Review
- Molecular and cellular bases of adaptation to a changing environment in microorganisms.Proceedings. Biological sciences · 2016Review
- Ongoing resolution of duplicate gene functions shapes the diversification of a metabolic network.eLife · 2016Article
- Bulk Segregant Analysis Reveals the Genetic Basis of a Natural Trait Variation in Fission Yeast.Genome biology and evolution · 2015Article
- Crowded growth leads to the spontaneous evolution of semistable coexistence in laboratory yeast populations.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Allelic variation, aneuploidy, and nongenetic mechanisms suppress a monogenic trait in yeast.Genetics · 2015Article
- Evolving a 24-hr oscillator in budding yeast.eLife · 2014Article
- Fitness is strongly influenced by rare mutations of large effect in a microbial mutation accumulation experiment.Genetics · 2014Article
- An evaluation of high-throughput approaches to QTL mapping in Saccharomyces cerevisiae.Genetics · 2014Article
- The genetic causes of convergent evolution.Nature reviews. Genetics · 2013Review
- High-resolution mapping of complex traits with a four-parent advanced intercross yeast population.Genetics · 2013Article
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Abstract
Understanding the genetic basis of evolutionary adaptation is limited by our ability to efficiently identify the genomic locations of adaptive mutations. Here we describe a method that can quickly and precisely map the genetic basis of naturally and experimentally evolved complex traits using linkage analysis. A yeast strain that expresses the evolved trait is crossed to a distinct strain background and DNA from a large pool of progeny that express the trait of interest is hybridized to oligonucleotide microarrays that detect thousands of polymorphisms between the two strains. Adaptive mutations are detected by linkage to the polymorphisms from the evolved parent. We successfully tested our method by mapping five known genes to a precision of 0.2-24 kb (0.1-10 cM), and developed computer simulations to test the effect of different factors on mapping precision. We then applied this method to four yeast strains that had independently adapted to a fluctuating glucose-galactose environment. All four strains had acquired one or more missense mutations in GAL80, the repressor of the galactose utilization pathway. When transferred into the ancestral strain, the gal80 mutations conferred the fitness advantage that the evolved strains show in the transition from glucose to galactose. Our results show an example of parallel adaptation caused by mutations in the same gene.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.