ArticleThe Journal of comparative neurology2006
Long hydrocarbon chains serve as unique molecular features recognized by ventral glomeruli of the rat olfactory bulb.
Article in The Journal of comparative neurology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Interaction between age and perceptual similarity in olfactory discrimination learning in F344 rats: relationships with spatial learning.Neurobiology of aging · 2017Article
- Cluster analysis of rat olfactory bulb responses to diverse odorants.Chemical senses · 2012Article
- Objective display and discrimination of floral odors from Amorphophallus titanum, bloomed on different dates and at different locations, using an electronic nose.Sensors (Basel, Switzerland) · 2012Article
- The location of olfactory receptors within olfactory epithelium is independent of odorant volatility and solubility.BMC research notes · 2011Article
- Is there a space-time continuum in olfaction?Cellular and molecular life sciences : CMLS · 2009Review
- Spatial representations of odorants in olfactory bulbs of rats and mice: similarities and differences in chemotopic organization.The Journal of comparative neurology · 2009Article
- Chemotopic odorant coding in a mammalian olfactory system.The Journal of comparative neurology · 2007Review
- Odorants with multiple oxygen-containing functional groups and other odorants with high water solubility preferentially activate posterior olfactory bulb glomeruli.The Journal of comparative neurology · 2007Article
- Responses of the rat olfactory epithelium to retronasal air flow.Journal of neurophysiology · 2007Article
- Effects of double and triple bonds on the spatial representations of odorants in the rat olfactory bulb.The Journal of comparative neurology · 2007Article
- Predicting odorant quality perceptions from multidimensional scaling of olfactory bulb glomerular activity patterns.Behavioral neuroscience · 2006Article
- Differential responses to branched and unsaturated aliphatic hydrocarbons in the rat olfactory system.The Journal of comparative neurology · 2006Article
- Differential specificity in the glomerular response profiles for alicyclic, bicyclic, and heterocyclic odorants.The Journal of comparative neurology · 2006Article
- Chemotopic representations of aromatic odorants in the rat olfactory bulb.The Journal of comparative neurology · 2006Article
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3 authors.
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Abstract
In an effort to understand mammalian olfactory processing, we have been describing the responses to systematically different odorants in the glomerular layer of the main olfactory bulb of rats. To understand the processing of pure hydrocarbon structures in this system, we used the [(14)C]2-deoxyglucose method to determine glomerular responses to a homologous series of alkanes (from six to 16 carbons) that are straight-chained hydrocarbons without functional groups. We found two rostral regions of activity evoked by these odorants, one lateral and one medial, that were observed to shift ventrally with increasing alkane carbon chain length. Furthermore, we successfully predicted that the longest alkanes with carbon chain length greater than our previous odorant selections would stimulate extremely ventral glomerular regions where no activation had been observed with the hundreds of odorants that we had previously studied. Overlaps in response profiles were observed in the patterns evoked by alkanes and by other aliphatic odorants of corresponding carbon chain length despite possessing different oxygen-containing functional groups, which demonstrated that hydrocarbon chains could serve as molecular features in the combinatorial coding of odorant information. We found a close and predictable relationship among the molecular properties of odorants, their induced neural activity, and their perceptual similarities.
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