Evidence map›Paper›PMID 16856111›Full record

SynthesisThe Cochrane database of systematic reviews2006

Continuous cardiotocography (CTG) as a form of electronic fetal monitoring (EFM) for fetal assessment during labour.

Z Alfirevic, D Devane, G M L Gyte

2 registry-linked trialsAbstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in The Cochrane database of systematic reviews, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 241 papers, 18 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
241citing papers in PubMed, 18 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03231007 completednot on this mapstarted 2017, after this paper: background citation

Saving Babies' Lives Project Impact and Results Evaluation: a Mixed Methodology Study

TypeobservationalSponsorUniversity of ManchesterRan2017 to 2018Enrolled4,952ConditionsStillbirthArmsQuestionnaire
NCT05778435 nacompletednot on this mapstarted 2021, after this paper: background citation

The Effect Of The Wireless Fetal Monitoring Used During Birth On The Women's Comfort, Labour Pain And Birth Satisfaction

TypeinterventionalSponsorTokat Gaziosmanpasa UniversityRan2021 to 2021Enrolled88ConditionsPregnancy RelatedArmswireless fetal monitoring system
3 · Its place in the literature

Who cites it

241 citing papers in PubMed, 18 syntheses or guidelines pooled it, 1,042 citations in OpenAlex.

  1. Association between intrapartum fetal pulse oximetry and adverse perinatal and long-term outcomes: A systematic review and meta-analysis.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025
    Pooled it
  2. Pooled it
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  4. Fetal scalp stimulation for assessing fetal well-being during labour.The Cochrane database of systematic reviews · 2023
    Pooled it
  5. Computation of Fetal Kicking in Various Fetal Health Examinations: A Systematic Review.International journal of environmental research and public health · 2022
    Pooled it
  6. Pooled it
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  8. Systematic review of Doppler for detecting intrapartum fetal heart abnormalities and measuring perinatal mortality in low- and middle-income countries.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2020
    Pooled it
  9. Pooled it
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  11. Pooled it
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  13. Fetal electrocardiogram (ECG) for fetal monitoring during labour.The Cochrane database of systematic reviews · 2015
    Pooled it
  14. Fetal movement counting for assessment of fetal wellbeing.The Cochrane database of systematic reviews · 2015
    Pooled it
  15. Antenatal cardiotocography for fetal assessment.The Cochrane database of systematic reviews · 2015
    Pooled it
  16. Pooled it
  17. Pooled it
  18. Fetal pulse oximetry for fetal assessment in labour.The Cochrane database of systematic reviews · 2014
    Pooled it
  19. Trial
  20. Trial

181 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

Z AlfirevicUniversity of Liverpool, Division of Perinatal and Reproductive Medicine, First Floor, Liverpool Women's NHS Foundation Trust, Crown Street, Liverpool, UK L8 7SS. zarko@liverpool.ac.uk
D Devane
G M L Gyte
Liverpool Womens NHS Foundation Trust · GBOllscoil na Gaillimhe – University of Galway · IEUniversity of Liverpool · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCardiotocography (sometimes known as electronic fetal monitoring), records changes in the fetal heart rate and their temporal relationship to uterine contractions. The aim is to identify babies who may be short of oxygen (hypoxic), so additional assessments of fetal well-being may be used, or the baby delivered by caesarean section or instrumental vaginal birth.

objectivesTo evaluate the effectiveness of continuous cardiotocography during labour. SEARCH STRATEGY: We searched the Cochrane Pregnancy and Childbirth Group Trials Register (March 2006), CENTRAL (The Cochrane Library 2005, Issue 4), MEDLINE (1966 to December 2005), EMBASE (1974 to December 2005), Dissertation Abstracts (1980 to December 2005) and the National Research Register (December 2005). SELECTION CRITERIA: Randomised and quasi-randomised controlled trials involving a comparison of continuous cardiotocography (with and without fetal blood sampling) with (a) no fetal monitoring, (b) intermittent auscultation (c) intermittent cardiotocography. DATA COLLECTION AND ANALYSIS: Two authors independently assessed eligibility, quality and extracted data. MAIN

resultsTwelve trials were included (over 37,000 women); only two were high quality. Compared to intermittent auscultation, continuous cardiotocography showed no significant difference in overall perinatal death rate (relative risk (RR) 0.85, 95% confidence interval (CI) 0.59 to 1.23, n = 33,513, 11 trials), but was associated with a halving of neonatal seizures (RR 0.50, 95% CI 0.31 to 0.80, n = 32,386, nine trials) although no significant difference was detected in cerebral palsy (RR 1.74, 95% CI 0.97 to 3.11, n = 13,252, two trials). There was a significant increase in caesarean sections associated with continuous cardiotocography (RR 1.66, 95% CI 1.30 to 2.13, n =18,761, 10 trials). Women were also more likely to have an instrumental vaginal birth (RR 1.16, 95% CI 1.01 to 1.32, n = 18,151, nine trials). Data for subgroups of low-risk, high-risk, preterm pregnancies and high quality trials were consistent with overall results. Access to fetal blood sampling did not appear to influence the difference in neonatal seizures nor any other prespecified outcome. AUTHORS'

conclusionsContinuous cardiotocography during labour is associated with a reduction in neonatal seizures, but no significant differences in cerebral palsy, infant mortality or other standard measures of neonatal well-being. However, continuous cardiotocography was associated with an increase in caesarean sections and instrumental vaginal births. The real challenge is how best to convey this uncertainty to women to enable them to make an informed choice without compromising the normality of labour.

Indexed as

Labor, ObstetricCardiotocographyCesarean SectionFemaleHeart AuscultationHumansInfant MortalityInfant, NewbornPregnancyRandomized Controlled Trials as Topic

Identifiers

PMID16856111
OpenAlexW2146446882

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.