ArticleJournal of human hypertension2006
Inflammation, obesity and cardiovascular function in African and Caucasian women from South Africa: the POWIRS study.
Article in Journal of human hypertension, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- Review: Metabolic Syndrome in Black South African Women.Ethnicity & disease · 2017Pooled it
- Obesity and its health impact in Africa: a systematic review.Cardiovascular journal of Africa · 2012Pooled it
- Lower Socioeconomic Status Predicts Increased Proinflammatory Signaling in Late Pregnancy: Evidence From a Filipino Cohort.American journal of human biology : the official journal of the Human Biology Council · 2024Article
- Article
- Targeted proteomics of appendicular skeletal muscle mass and handgrip strength in black South Africans: a cross-sectional study.Scientific reports · 2022Article
- Obesity and CKD in Sub-Saharan Africa: A Narrative Review.Kidney medicine · 2022Review
- Inflammation and salt in young adults: the African-PREDICT study.European journal of nutrition · 2021Article
- The association between high-sensitivity C-reactive protein and blood pressure in Yi people.BMC public health · 2019Article
- Do gender and ethnic differences in fasting leptin in Indians and Creoles of Mauritius persist beyond differences in adiposity?International journal of obesity (2005) · 2018Article
- Prevalence, Risk Factors, and Pathophysiology of Dysglycemia among People Living with HIV in Sub-Saharan Africa.Journal of diabetes research · 2018Review
- Recent advances in understanding hypertension development in sub-Saharan Africa.Journal of human hypertension · 2017Review
- Change in renin, cardiovascular and inflammatory markers over three years in a black and white population: the SABPA study.BMC cardiovascular disorders · 2017Article
- Monocyte Chemoattractant Protein-1 and Large Artery Structure and Function in Young Individuals: The African-PREDICT Study.Journal of clinical hypertension (Greenwich, Conn.) · 2017Article
- High-Sensitivity C-Reactive Protein and Cardiovascular Disease Across Countries and Ethnicities.Clinics (Sao Paulo, Brazil) · 2016Review
- Racial Disparities in the Pathogenesis of Type 2 Diabetes and its Subtypes in the African Diaspora: A New Paradigm.Journal of racial and ethnic health disparities · 2016Article
- Inflammation as Possible Mediator for the Relationship Between Lung and Arterial Function.Lung · 2016Article
- The Association of Endothelin-1 with Markers of Arterial Stiffness in Black South African Women: The SABPA Study.Journal of amino acids · 2015Article
- Consequences of Abdominal Adiposity within the Metabolic Syndrome Paradigm in Black People of African Ancestry.Journal of clinical medicine · 2014Review
- Characterization of transcriptional complexity during adipose tissue development in bovines of different ages and sexes.PloS one · 2014Article
- Rheumatoid arthritis is associated with reduced adiposity but not with unfavorable major cardiovascular risk factor profiles and enhanced carotid atherosclerosis in black Africans from a developing population: a cross-sectional study.Arthritis research & therapy · 2013Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The integrated relationship between inflammation, obesity and cardiovascular disease is currently a subject of much research interest. These specific relationships, however, have not been studied in-depth in South African population groups in order to determine the role of ethnicity. It is known that Africans, compared to Caucasians, suffer from a high prevalence of hypertension. It was therefore hypothesized that the levels of inflammatory markers (high-sensitivity C-reactive protein (hsCRP), fibrinogen and leptin) are higher in Africans compared to Caucasians and are notably associated with cardiovascular dysfunction in Africans. Apparently healthy African (N=102) and Caucasian (N=115) women, matched for age and body mass index (BMI), were recruited. Leptin, hsCRP, fibrinogen and lipid levels, waist circumference (WC), BMI, systolic and diastolic blood pressure, cardiac output (CO), total peripheral resistance (TPR) and Windkessel compliance were measured. Results showed that the levels of leptin, hsCRP and fibrinogen were significantly higher (P<0.05) in the African women. The inflammatory markers correlated strongly with cardiovascular parameters, age and obesity (BMI, WC) in both groups, but after adjusting for age and obesity, none of the correlations were significant anymore. Multiple regression analyses (with leptin, hsCRP or fibrinogen as dependent variable) showed that only leptin levels of African women were explained by cardiovascular parameters (BP, TPR and CO). In conclusion, even though African women had significantly higher leptin, hsCRP, fibrinogen and blood pressure levels than Caucasian women, no cardiovascular parameters explained the variation in the inflammatory markers (except for leptin levels of African women).
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