ArticleJournal of bacteriology2006
UvrD helicase suppresses recombination and DNA damage-induced deletions.
Article in Journal of bacteriology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 39 citations in OpenAlex.
- The SOS response acts as a regulatory switch that balances helicase anti-recombination with transcription-replication conflict resolution activities in Escherichia coli.G3 (Bethesda, Md.) · 2026Article
- Review
- Role of DEAD/DEAH-box helicases in immunity, infection and cancers.Cell communication and signaling : CCS · 2025Review
- Genetic Determinants in Salmonella enterica Serotype Typhimurium Required for OvercomingMicrobiology spectrum · 2021Article
- Molecular characterization of stress tolerance genes associated with D. indicus strain under extreme environment conditions.Environmental geochemistry and health · 2021Article
- The methylation-independent mismatch repair machinery inMicrobiology (Reading, England) · 2021Review
- Article
- Comparative proteomic analysis of Neisseria meningitidis wildtype and dprA null mutant strains links DNA processing to pilus biogenesis.BMC microbiology · 2017Article
- DprB facilitates inter- and intragenomic recombination in Helicobacter pylori.Journal of bacteriology · 2012Article
- The nucleotide excision repair (NER) system of Helicobacter pylori: role in mutation prevention and chromosomal import patterns after natural transformation.BMC microbiology · 2012Article
- The RecRO pathway of DNA recombinational repair in Helicobacter pylori and its role in bacterial survival in the host.DNA repair · 2011Article
- Recombination and DNA repair in Helicobacter pylori.Annual review of microbiology · 2011Review
- Relationship between operon preference and functional properties of persistent genes in bacterial genomes.BMC genomics · 2010Article
- Host-dependent Lewis (Le) antigen expression in Helicobacter pylori cells recovered from Leb-transgenic mice.The Journal of experimental medicine · 2009Article
- Subcellular proteomic characterization of the high-temperature stress response of the cyanobacterium Spirulina platensis.Proteome science · 2009Article
- Characterization of the mycobacterial NER system reveals novel functions of the uvrD1 helicase.Journal of bacteriology · 2009Article
- A RecB-like helicase in Helicobacter pylori is important for DNA repair and host colonization.Infection and immunity · 2009Article
- Unveiling novel RecO distant orthologues involved in homologous recombination.PLoS genetics · 2008Article
- Repair and antirepair DNA helicases in Helicobacter pylori.Journal of bacteriology · 2008Article
- Expedient placement of two fluorescent dyes for investigating dynamic DNA protein interactions in real time.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
UvrD, a highly conserved helicase involved in mismatch repair, nucleotide excision repair (NER), and recombinational repair, plays a critical role in maintaining genomic stability and facilitating DNA lesion repair in many prokaryotic species. In this report, we focus on the UvrD homolog in Helicobacter pylori, a genetically diverse organism that lacks many known DNA repair proteins, including those involved in mismatch repair and recombinational repair, and that is noted for high levels of inter- and intragenomic recombination and mutation. H. pylori contains numerous DNA repeats in its compact genome and inhabits an environment rich in DNA-damaging agents that can lead to increased rearrangements between such repeats. We find that H. pylori UvrD functions to repair DNA damage and limit homologous recombination and DNA damage-induced genomic rearrangements between DNA repeats. Our results suggest that UvrD and other NER pathway proteins play a prominent role in maintaining genome integrity, especially after DNA damage; thus, NER may be especially critical in organisms such as H. pylori that face high-level genotoxic stress in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.